ArticleJournal of the American Heart Association2025
Social Isolation Is Associated With the Acceleration of Death and Incident Cardiovascular Disease in Adults With Chronic Kidney Disease.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Article
- Social Disconnection, Genetic Risk, and the Incidence of Degenerative Valvular Heart Disease: A Population-Based Cohort Study.Journal of the American Heart Association · 2026Article
- The relationship between post-traumatic growth and social participation in patients receiving maintenance dialysis: cross-lagged analysis of two waves.Health psychology and behavioral medicine · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIndividuals with chronic kidney disease are at markedly increased risk of incident cardiovascular diseases (CVDs) and premature death. The impact of social isolation on adverse outcomes in chronic kidney disease remained understudied.
methodsThis prospective cohort study included 13 090 individuals with chronic kidney disease from the UK Biobank. The exposure was social isolation categorized into 3 levels: least, moderately, and most isolated. Using accelerated failure time and restricted mean survival time analyses.
resultsCompared with being least isolated, moderate and most isolation are associated with the acceleration of all-cause death with a time ratio of 0.87 (95% CI, 0.82-0.93;
conclusionsSocial isolation is associated with shortened survival and accelerates the onset of CVD in individuals with chronic kidney disease. Social support warrants attention in the prevention of death and CVD in these high-risk individuals.
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