ArticleAdvanced healthcare materials2025
Pyrophosphate-Containing Calcium Phosphates Negatively Impact Heterotopic Bone Quality.
Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Fabrication and characterization of biodegradable Zn-Ni spinel ferrite/ β-TCP composite ceramics exhibiting enhanced cell colonization.Journal of materials science. Materials in medicine · 2026Article
- Mind the gap: Standardising preclinical testing of bone-repair biomaterials.Biomaterials and biosystems · 2025Review
- Article
- Pyrophosphate-Containing Calcium Phosphates Negatively Impact Heterotopic Bone Quality.Advanced healthcare materials · 2025Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In bone, critical size defects pose substantial challenge in maxillofacial and orthopedic reconstructions as they are incapable of spontaneous regeneration. In such cases, autografts, allografts, and bone graft substitutes are used. Calcium phosphates (CaP) are widely used bone graft substitutes due to their biocompatibility, osteoconductive properties, and potential for osteoinductivity. CaP materials containing monetite, beta-tricalcium phosphate (β-TCP), and a small amount of calcium pyrophosphate (Ca-PP) possess both osteoconductive and osteoinductive properties. However, the role of Ca-PP in osteoinduction and material degradation remains unexplored. This study investigates heterotopic bone formation in response to five CaP compositions, maintaining a constant monetite to β-TCP ratio, with varying amounts of Ca-PP (0-12.5%). Twelve adult female sheep (Ovis aries) are subcutaneously implanted with constructs made of six CaP tiles interconnected by a Ti6Al4V frame and a control implant. Histological analysis, backscattered electron scanning electron microscopy, and Raman spectroscopy of samples retrieved at 12- and 52 weeks reveal that Ca-PP does not hinder heterotopic bone formation and minimally impacts CaP degradation. While monetite and β-TCP transform into apatite, the Ca-PP phase remains unchanged. The addition of Ca-PP to the CaP influences heterotopic bone quality and inflammatory response during tissue regeneration.
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