Evidence map›Paper›PMID 40401373›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2025

Placental Vascular Defects and Embryonic Lethality Triggered by TFPIα Deficiency in Factor V Leiden Mice.

Amy E Siebert, Susan A Maroney, Nicholas D Martinez, Michael J Soares, Alan E Mast

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amy E SiebertThrombosis and Hemostasis Program, Versiti Blood Research Institute, Milwaukee, WI (A.E.S., S.A.M., N.D.M., A.E.M.).ORCID 0000-0002-9634-9164
Susan A MaroneyThrombosis and Hemostasis Program, Versiti Blood Research Institute, Milwaukee, WI (A.E.S., S.A.M., N.D.M., A.E.M.).ORCID 0000-0002-8021-0694
Nicholas D MartinezThrombosis and Hemostasis Program, Versiti Blood Research Institute, Milwaukee, WI (A.E.S., S.A.M., N.D.M., A.E.M.).ORCID 0009-0002-6540-4076
Michael J SoaresInstitute for Reproductive and Developmental Sciences (M.J.S.), University of Kansas Medical Center.ORCID 0000-0001-7158-1592
Alan E MastThrombosis and Hemostasis Program, Versiti Blood Research Institute, Milwaukee, WI (A.E.S., S.A.M., N.D.M., A.E.M.).ORCID 0000-0003-3740-0318

Funding

TROPHOBLAST DIFFERENTIATIONR01HD020676 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MICHAEL J SOARES · 1986 to 2026
$10.1M
Tissue Factor Pathway Inhibitor Binding Proteins on EndoR01HL068835 · NHLBI · VERSITI WISCONSIN, INC. · PI Alan E Mast · 2002 to 2026
$9.7M
RESEARCH TRAINING IN TRANSFUSION SCIENCET32HL007209 · NHLBI · VERSITI WISCONSIN, INC. · PI WHITE, II, GILBERT C. · 1985 to 2019
$2.9M
Pre-mRNA Processing and Function of Alternatively Spliced Isoforms of TFPIR00HL163412 · NHLBI · OAKLAND UNIVERSITY · PI Amy Siebert-McKenzie · 2025 to 2026
$498k
Pre-mRNA Processing and Function of Alternatively Spliced Isoforms of TFPIK99HL163412 · NHLBI · VERSITI WISCONSIN, INC. · PI SIEBERT-MCKENZIE, AMY · 2023 to 2024
$233k
NHLBI NIH HHS K99 HL163412NHLBI NIH HHS R00 HL163412NHLBI NIH HHS R01 HL068835NHLBI NIH HHS T32 HL007209NICHD NIH HHS R01 HD020676
6 · The paper itself

Abstract

backgroundTFPI (tissue factor pathway inhibitor) inhibits the initiation of blood coagulation. TFPIα (TFPI alpha isoform), the only alternatively spliced TFPI isoform in platelets, is abundant in placenta and uniquely inhibits prothrombinase (FXa [activated factor X]-FVa [activated factor V]). This inhibitory activity is reduced when prothrombinase is assembled with FVL (factor V Leiden).

methodsEffects of TFPIα (

resultsGenotype frequencies were assessed and revealed that

conclusionsThese findings suggest that TFPIα and its inhibition of prothrombinase play an important role in placental angiogenesis and embryonic survival.

Indexed as

Factor VLipoproteinsPlacentaAnimalsBlood CoagulationBlood PlateletsDisease Models, AnimalFemaleFetal DeathHomozygoteMiceMice, Inbred C57BLMice, KnockoutPhenotypePregnancyFactor Vfactor V Leidenlipoprotein-associated coagulation inhibitorLipoproteinsangiogenesismiceplacentapregnancythrombin

Identifiers

PMID40401373
PMCPMC12197823

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.