Evidence map›Paper›PMID 40401366›Full record

ArticleAIDS patient care and STDs2025

Using Structural Equation Modeling to Examine Barriers and Facilitators of HIV Pre-Exposure Prophylaxis Willingness and Length of Use in Men Who Have Sex with Men Who Use Substances in Eight Southern US Cities.

Melissa M Ertl, Christina Woodhouse, David Meche, David W Forrest, Joshua Fegley, Margaret Paschen-Wolff, Tanja C Laschober, Mary A Hatch, C Mindy Nelson, Lynette Wright and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS patient care and STDs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Melissa M ErtlDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-1022-1777
Christina WoodhouseJasmyn, Jacksonville, Florida, USA.
David MecheOpen Health Care Clinic, Baton Rouge, Louisiana, USA.
David W ForrestDepartment of Anthropology, University of Miami, Miami, Florida, USA.
Joshua FegleyCrescentCare, New Orleans, Louisiana, USA.
Margaret Paschen-WolffColumbia University Irving Medical Center, New York, New York, USA.
Tanja C LaschoberDepartment of Psychiatry & Behavioral Sciences, Addictions, Drug & Alcohol Institute, University of Washington School of Medicine, Seattle, Washington, USA.
Mary A HatchDepartment of Psychiatry & Behavioral Sciences, Addictions, Drug & Alcohol Institute, University of Washington School of Medicine, Seattle, Washington, USA.
C Mindy NelsonDepartment of Public Health Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA.
Lynette WrightDepartment of Psychiatry & Behavioral Sciences, Addictions, Drug & Alcohol Institute, University of Washington School of Medicine, Seattle, Washington, USA.
Susan TrossColumbia University Irving Medical Center, New York, New York, USA.

Funding

Project-003UG1DA013035 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Aimee N Campbell, Jennifer McNeely · 2015 to 2026
$130.3M
The Statistics, Data Science, and Data Management (SDM) CoreP30MH043520 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MILTON L WAINBERG · 2003 to 2026
$48.2M
Clinical Trials Network: Pacific Northwest Node (CTN-0082, -0131, -0139 and dissemination library)UG1DA013714 · NIDA · UNIVERSITY OF WASHINGTON · PI Mary Akiko Hatch, John M. Roll · 2015 to 2026
$19.8M
Enhanced Interdisciplinary Research Training InstituteR25DA050687 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VALDEZ, AVELARDO · 2020 to 2024
$1.3M
NIDA NIH HHS R25 DA050687NIDA NIH HHS UG1 DA013035NIDA NIH HHS UG1 DA013714NIMH NIH HHS P30 MH043520
6 · The paper itself

Abstract

Men who have sex with men who use substances (SU-MSM) can benefit from pre-exposure prophylaxis (PrEP) for HIV prevention, especially in Southern US cities where HIV incidence is high; however, uptake remains low. Identifying barriers and facilitators is crucial for developing and implementing strategies to enhance uptake. Few studies of PrEP barriers and facilitators have focused on Southern SU-MSM, and most existing studies have not robustly measured such barriers and facilitators. In this study, 225 SU-MSM were recruited from community STI clinics, syringe services programs, or substance use treatment programs in eight Southern cities. Using structural equation modeling, we examined latent variable constructs of barriers and facilitators (i.e., affordability, burden, risk compensation, side effects, and stigma) and their associations with both willingness to take PrEP and length of PrEP use. Greater concern over affordability was robustly associated with more willingness to take PrEP under a variety of conditions. Risk compensation was associated with greater length of PrEP use, suggesting a major motivator to remain on PrEP was the perceived freedom to forego condoms during sex. Findings advance research on measurement of barriers and facilitators of PrEP willingness and uptake and highlight the importance of addressing affordability in PrEP implementation.

Indexed as

Anti-HIV AgentsHIV InfectionsHomosexuality, MalePatient Acceptance of Health CarePre-Exposure ProphylaxisSubstance-Related DisordersAdultCitiesHealth Knowledge, Attitudes, PracticeHealth Services AccessibilityHumansLatent Class AnalysisMaleMiddle AgedSocial StigmaUnited StatesAnti-HIV AgentsHIV preventionmen who have sex with menPrEPsubstance use

Identifiers

PMID40401366
PMCPMC12172640

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.