Evidence map›Paper›PMID 40401209›Full record

ArticleARYA atherosclerosis2025

Predicting the presence and severity of coronary artery disease using surrogate markers of insulin resistance: A cross-sectional study.

Soodeh Jahangiri, Seyed Arad Mosalamiaghili, Reza Heydarzadeh, Mohammadali Yousefzadeh, Reza Golchin Vafa, Hooyar Zarifkar, Kasra Assadian, Sina Sohrabizadeh, Hourshad Zarifkar, Mehrdad Sadeghi and 4 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ARYA atherosclerosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06237244 (Predicting the Presence and Severity of Coronary Artery Disease Using Surrogate Markers of Insulin Resistance), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06237244 completednot on this map

Predicting the Presence and Severity of Coronary Artery Disease Using Surrogate Markers of Insulin Resistance: A Cross-Sectional Study

Typeobservational_patient_registrySponsorShiraz University of Medical SciencesRan2018 to 2023Enrolled1,017ConditionsInsulin Resistance, Coronary Artery DiseaseArmstriglyceride to glucose ratio, triglycerdie to HDL ratio
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Soodeh JahangiriEndocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.
Seyed Arad MosalamiaghiliStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Reza HeydarzadehShiraz University of Medical Sciences, Shiraz, Iran.
Mohammadali YousefzadehDepartment of Civil and Environmental Engineering, Shiraz University, Shiraz, Iran.
Reza Golchin VafaShiraz University of Medical Sciences, Shiraz, Iran.
Hooyar ZarifkarShiraz University of Medical Sciences, Shiraz, Iran.
Kasra AssadianStudent Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Sina SohrabizadehShiraz University of Medical Sciences, Shiraz, Iran.
Hourshad ZarifkarShiraz University of Medical Sciences, Shiraz, Iran.
Mehrdad SadeghiProfessor Kojuri Cardiology Clinic, Shiraz, Iran.
Nazanin HosseiniProfessor Kojuri Cardiology Clinic, Shiraz, Iran.
Mohammad MontaseriProfessor Kojuri Cardiology Clinic, Shiraz, Iran.
Seyed Ali HosseiniProfessor Kojuri Cardiology Clinic, Shiraz, Iran.
Javad KojuriShiraz University of Medical Sciences, Shiraz, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio, Metabolic Score for Insulin Resistance (METS-IR), triglyceride-glucose (TyG) index, and triglyceride-glucose body mass index (TyG-BMI) have been associated with the occurrence and severity of coronary artery disease (CAD), although evidence remains limited.

methodsA total of 1,017 patients undergoing coronary angiography for the first time were included. Insulin resistance (IR) indices were calculated based on patients' laboratory data. Significant CAD was defined as more than 50% stenosis observed in coronary angiography

resultsA positive correlation was found between CAD and the TyG index (ρ = 0.083, p = 0.008). Patients with CAD had a significantly elevated TyG index (9.02 ± 0.62) compared to those with single-vessel disease (SVD) (8.87 ± 0.59) (p = 0.012). A strong association was observed between CAD and the TG/HDL-C ratio (ρ = 0.114, p < 0.001). Patients with multi-vessel disease exhibited a considerably higher index (4.47 ± 2.46) compared to those with SVD (3.77 ± 2.45) (p = 0.003). The TyG index cut-off was 9.22 (27.5% sensitivity, 79.3% specificity, 82.2% positive predictive value (PPV), and 23.89% negative predictive value (NPV)), while the TG/HDL-C ratio cut-off was 3.6 (44% sensitivity, 65.2% specificity, 81.5% PPV, and 25.5% NPV).

conclusionOur findings indicate that the TG/HDL-C ratio, with a cut-off point of 3.6, and the TyG index, with a threshold of 9.22, are associated with the presence of CAD. (ClinicalTrials.gov registration number: NCT06237244).

Indexed as

Coronary Artery DiseaseInsulin Resistance Indices

Identifiers

PMID40401209
PMCPMC12091249

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.