Evidence map›Paper›PMID 40401168›Full record

ArticleEnvironmental epigenetics2025

Prenatal per- and polyfluoroalkyl substance exposures and DNA methylation among newborns in the Environmental influences on Child Health Outcomes program.

Rose Schrott, Christine Ladd-Acosta, Vasantha Padmanabhan, Dana Boyd Barr, Carrie V Breton, Andres Cardenas, Courtney C Carignan, Dana Dabelea, Anne L Dunlop, Danielle M Fallin and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Rose SchrottDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, United States.ORCID https://orcid.org/0000-0001-8224-9245
Christine Ladd-AcostaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, United States.ORCID https://orcid.org/0000-0002-7697-3998
Vasantha PadmanabhanDepartment of Pediatrics, University of Michigan, Ann Arbor, MI 48109, United States.ORCID https://orcid.org/0000-0002-8443-7212
Dana Boyd BarrGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, United States.
Carrie V BretonDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA 90033, United States.ORCID https://orcid.org/0000-0002-6082-4066
Andres CardenasDepartment of Epidemiology and Population Health, Stanford University, Stanford, CA 94305, United States.
Courtney C CarignanDepartment of Food Science and Human Nutrition, Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, United States.
Dana DabeleaLifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States.ORCID https://orcid.org/0000-0001-9514-8929
Anne L DunlopDepartment of Gynecology and Obstetrics, School of Medicine, Emory University, Atlanta, GA 30322, United States.
Danielle M FallinRollins School of Public Health, Emory University, Atlanta, GA 30322, United States.
Marie-France HivertDivision of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA 02215, United States.
Ellen M HowertonDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, United States.
Anna K KnightDepartment of Gynecology and Obstetrics, School of Medicine, Emory University, Atlanta, GA 30322, United States.
Emily OkenDivision of Chronic Disease Research Across the Lifecourse (CoRAL), Department of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA 02215, United States.ORCID https://orcid.org/0000-0003-2513-3339
Alicia K PetersonDivision of Research, Kaiser Permanente Northern California, Pleasanton, Pleasanton 94588 United States.
Michael C PetrielloDepartment of Pharmacology, Wayne State University, Detroit, MI 48201, United States.
Douglas RudenDepartment of Obstetrics and Gynecology, Institute of Environmental Health Sciences, Wayne State University, Detroit, MI 48201, United States.
Rebecca J SchmidtDepartment of Public Health Sciences and the MIND Institute, University of California Davis School of Medicine, Davis, CA 95817, United States.ORCID https://orcid.org/0000-0003-1582-2747
Alicia K SmithDepartment of Gynecology and Obstetrics, School of Medicine, Emory University, Atlanta, GA 30322, United States.
Anne P StarlingLifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States.ORCID https://orcid.org/0000-0002-6638-8314
Ivana V YangDepartment of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, United States.
Yeyi ZhuDivision of Research, Kaiser Permanente Northern California, Pleasanton, Pleasanton 94588 United States.ORCID https://orcid.org/0000-0002-7296-738X
Jaclyn M GoodrichDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, United States.ORCID https://orcid.org/0000-0002-8289-9253

Funding

Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
Prenatal Environment And Child Health (PEACH) in ECHOUH3OD035550 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Rebecca Jean Schmidt · 2025 to 2026
$4.0M
Prenatal Environment And Child Health (PEACH) in ECHOUG3OD035550 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SCHMIDT, REBECCA JEAN · 2023 to 2024
$3.2M
NIEHS NIH HHS P30 ES017885NIH HHS UG3 OD035550NIH HHS UH3 OD035550
6 · The paper itself

Abstract

Gestation is a vulnerable window when exposure to per- and polyfluoroalkyl substances (PFAS) may impact child development and health. Epigenetic modification, including DNA methylation (DNAm), may be one mechanism linking prenatal PFAS exposure to offspring outcomes. We tested associations between prenatal PFAS and newborn DNAm in 1017 participants from 6 cohorts in the US Environmental influences on Child Health Outcomes consortium. Concentrations of PFAS [perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexanesulfonic acid (PFHxS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid] were measured in maternal serum or plasma. DNAm was quantified in newborn dried blood spot or umbilical cord blood leukocytes using the Infinium HumanMethylation450 (450K) or MethylationEPIC (EPIC) arrays. We tested associations between prenatal PFAS and neonatal blood DNAm on the 450K (

Indexed as

children’s healthdevelopmental origins of health and diseaseDNA methylationepigeneticsepigenomicsper- and polyfluoroalkyl substancesperfluorinated chemicals

Identifiers

PMID40401168
PMCPMC12094075

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.