Evidence map›Paper›PMID 40401166›Full record

ArticleEnvironmental epigenetics2025

Silencing

Anthony P Brown, Sreeja Parameswaran, Lucy Cai, Sweeney Elston, Chi Pham, Artem Barski, Matthew T Weirauch, Hong Ji

Abstract read
In one paragraph

Article in Environmental epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Anthony P BrownCalifornia National Primate Research Center, University of California Davis, Davis, CA 95616, United States.
Sreeja ParameswaranCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States.
Lucy CaiCalifornia National Primate Research Center, University of California Davis, Davis, CA 95616, United States.
Sweeney ElstonCalifornia National Primate Research Center, University of California Davis, Davis, CA 95616, United States.
Chi PhamCalifornia National Primate Research Center, University of California Davis, Davis, CA 95616, United States.
Artem BarskiDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States.ORCID https://orcid.org/0000-0002-1861-5316
Matthew T WeirauchCenter for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, United States.
Hong JiCalifornia National Primate Research Center, University of California Davis, Davis, CA 95616, United States.ORCID https://orcid.org/0000-0002-9558-0620

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
UC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Irva Hertz-Picciotto · 2015 to 2026
$26.0M
Tissue Repository CoreP30AR070549 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Leah Claire Kottyan · 2016 to 2026
$7.7M
Dynamic regulatory network models of human response to influenza virusU01AI150748 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI MARAZZI, IVAN, MIRALDI, EMILY · 2020 to 2024
$5.8M
Role of TET1 in airway epithelium and childhood asthmaR01AI141569 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JI, HONG · 2019 to 2023
$3.0M
SciDAP: Scientific Data Analysis PlatformR42HG011219 · NHGRI · DATIRIUM, LLC · PI BARSKI, ARTEM, KARTASHOV, ANDREY · 2022 to 2023
$1.6M
NHGRI NIH HHS R42 HG011219NIAID NIH HHS R01 AI141569NIAID NIH HHS U01 AI150748NIAMS NIH HHS P30 AR070549NIEHS NIH HHS P30 ES023513NIH HHS P51 OD011107
6 · The paper itself

Abstract

Previous studies have demonstrated that ten-eleven translocation methylcytosine dioxygenase 1 (TET1) plays a protective role against house dust mite (HDM)-induced allergic airway inflammation. TET1 transcriptionally responded to HDM extract and regulated the expression of genes involved in asthma in human bronchial epithelial cells (HBECs). How TET1 regulates the expression of these genes, however, is unknown. To this end, we measured mRNA expression, DNA methylation, chromatin accessibility, and histone modifications in control and

Indexed as

asthmaATAC-seqchromatin accessibilityfunctional genomicsgene regulationmethylationRNA-seqTET1transcription factorwhole-genome bisulfite sequencing

Identifiers

PMID40401166
PMCPMC12094077

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.