Evidence map›Paper›PMID 40401117›Full record

ReviewInternational journal of physiology, pathophysiology and pharmacology2025

Artificial intelligence in automated detection of lung nodules: a narrative review.

Amirreza Khalaji, Farshad Riahi, Diana Rafieezadeh, Fahimeh Khademi, Shahin Fesharaki, Saeid Sadeghi Joni

Abstract readReview
In one paragraph

Review in International journal of physiology, pathophysiology and pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. A comparative study of artifact reduction techniques in metal-implanted CT scans.International journal of physiology, pathophysiology and pharmacology · 2026
    Review
  3. Review
  4. Tuberculous spondylodiscitis with ureteral involvement: a rare case report.American journal of clinical and experimental urology · 2025
    Article
  5. Using ultrasonographic features in pediatric Crohn's disease activity index severity.International journal of physiology, pathophysiology and pharmacology · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amirreza KhalajiDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University Atlanta, GA, USA.
Farshad RiahiDepartment of Radiology, School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran.
Diana RafieezadehDepartment of Cellular and Molecular Biology, Razi University Kermanshah, Iran.
Fahimeh KhademiDepartment of Radiology, School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran.
Shahin FesharakiDepartment of Radiology, School of Medicine, Isfahan University of Medical Sciences Isfahan, Iran.
Saeid Sadeghi JoniDepartment of Radiology, Razi Hospital, Guilan University of Medical Sciences Rasht, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer remains a leading cause of cancer-related mortality worldwide, and early detection is essential for improving patient outcomes. This study evaluates the role of artificial intelligence (AI) in lung nodule detection, focusing on its potential to enhance the accuracy of early lung cancer diagnosis. We assess the performance of AI tools, particularly convolutional neural networks (CNNs), in identifying and segmenting lung nodules from computed tomography (CT) and X-ray images. Our findings indicate that AI systems achieve a sensitivity of 70-90%, comparable to that of experienced radiologists, while reducing false-positive rates. In pulmonary nodule detection on CT scans, AI demonstrated over 95% sensitivity with fewer than one false-positive per scan. The implementation of AI as a "second reader" significantly improved detection accuracy. Despite these advancements, challenges remain, including high false-positive rates, issues with generalizability across diverse populations, regulatory concerns, and skepticism among healthcare professionals. This study highlights the promise of AI in supporting radiologists and improving lung cancer screening while emphasizing the need for further research to enhance specificity and address existing limitations.

Indexed as

Artificial intelligencelung nodulespulmonary nodule detection

Identifiers

PMID40401117
PMCPMC12089837

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.