ArticleFrontiers in allergy2025
Analysis of the multicomponent ALEX array data to examine patterns of sensitization in Cape Town, South Africa.
Article in Frontiers in allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Five years of national airborne pollen monitoring in South Africa: biome-specific calendars to inform allergy diagnosis and prevention.Aerobiologia · 2026Article
- Molecular sensitization clusters in adult atopy: an ALEXFrontiers in immunology · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: This study analysed allergen sensitization patterns in Cape Town, a biodiversity-rich region with a Mediterranean climate, using ALEX® and ALEX²® multiplex component-resolved diagnostics tools. It aimed to address gaps in allergen sensitisation pattern data and complement aerobiological monitoring. Methods and results: A retrospective review of 708 adults and children attending two tertiary allergy clinics (2019-2024) found that house dust mites were the most common allergens, affecting 50%-60% of participants, with Der p 23 particularly prevalent (53%). Grass pollen sensitization was also high (46%), with 85% sensitised to the C4 grass Bermuda. Tree pollen sensitisation occurred in 29% with 14% sensitised to a diverse range of trees but neither London plane nor Cypress currently recommended in limited testing panels. Common food allergens included fruits (30%), seafood (27%), and nuts (25%), often linked to pollen cross-reactivity. Conclusion: Our study confirms a known pattern of aeroallergen sensitisation for a coastal temperate region, with increasing pollen sensitisation, particular C4 grasses. Clinicians should be aware of the diversity of tree pollen sensitisation, cross-reactivity patterns between food and pollen sensitisations and rates of minor allergen sensitisations for Blomia and animal danders when considering allergen-immunotherapies.
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