Evidence map›Paper›PMID 40401108›Full record

ArticleAmerican journal of nuclear medicine and molecular imaging2025

Automatic synthesis of a phosphodiesterase 4B (PDE4B) radioligand and PET imaging in depression rodent models.

Chenchen Dong, Weijian Ye, Yi Xu, Jiahui Chen, Kai Liao, Huiyi Wei, Yuanfang Jiang, Lu Hou, Junjie Wei, Zhiqiang Tan and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Chenchen DongCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and Key Laboratory of Basic and Translational Research on Radiopharmaceuticals, The First Affiliated Hospital of Jinan University Guangzhou 510630, Guangdong, China.
Weijian YeCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and Key Laboratory of Basic and Translational Research on Radiopharmaceuticals, The First Affiliated Hospital of Jinan University Guangzhou 510630, Guangdong, China.
Yi XuDepartment of Cardiology, The First Affiliated Hospital of Jinan University Guangzhou 510630, Guangdong, China.
Jiahui ChenDepartment of Radiology and Imaging Sciences, Emory University 1364 Clifton Road, Atlanta, GA 30322, USA.
Kai LiaoCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and Key Laboratory of Basic and Translational Research on Radiopharmaceuticals, The First Affiliated Hospital of Jinan University Guangzhou 510630, Guangdong, China.
Huiyi WeiCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and Key Laboratory of Basic and Translational Research on Radiopharmaceuticals, The First Affiliated Hospital of Jinan University Guangzhou 510630, Guangdong, China.
Yuanfang JiangCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and Key Laboratory of Basic and Translational Research on Radiopharmaceuticals, The First Affiliated Hospital of Jinan University Guangzhou 510630, Guangdong, China.
Lu HouCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and Key Laboratory of Basic and Translational Research on Radiopharmaceuticals, The First Affiliated Hospital of Jinan University Guangzhou 510630, Guangdong, China.
Junjie WeiCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and Key Laboratory of Basic and Translational Research on Radiopharmaceuticals, The First Affiliated Hospital of Jinan University Guangzhou 510630, Guangdong, China.
Zhiqiang TanCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and Key Laboratory of Basic and Translational Research on Radiopharmaceuticals, The First Affiliated Hospital of Jinan University Guangzhou 510630, Guangdong, China.
Zhendong SongDepartment of Radiology and Imaging Sciences, Emory University 1364 Clifton Road, Atlanta, GA 30322, USA.
Yinlong LiDepartment of Radiology and Imaging Sciences, Emory University 1364 Clifton Road, Atlanta, GA 30322, USA.
Achi HaiderDepartment of Radiology and Imaging Sciences, Emory University 1364 Clifton Road, Atlanta, GA 30322, USA.
Hongjie YuanDepartment of Pharmacology and Chemical Biology, Emory University 1364 Clifton Road, Atlanta, GA 30322, USA.
Steven H LiangDepartment of Radiology and Imaging Sciences, Emory University 1364 Clifton Road, Atlanta, GA 30322, USA.
Lu WangCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and Key Laboratory of Basic and Translational Research on Radiopharmaceuticals, The First Affiliated Hospital of Jinan University Guangzhou 510630, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phosphodiesterase 4B (PDE4B) is an enzyme that hydrolyzes cyclic adenosine monophosphate (cAMP), a critical signaling molecule involved in various cellular processes. Dysregulated PDE4B activity has been implicated in psychiatric diseases like depression and schizophrenia. In this report, a PDE4B-targeted PET tracer, [

Indexed as

depression rat modelPhosphodiesterase 4Bpositron emission tomographyradioligand

Identifiers

PMID40401108
PMCPMC12089095

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.