Evidence map›Paper›PMID 40401100›Full record

ArticleACS catalysis2025

Reversible Substrate-Specific Photocontrol of the Chemotherapeutic Asparaginase(-Glutaminase) from

Mona Wieland, Jonnely Luizaga, Cristina Duran, Barbara Germscheid, Johanna Rein, Astrid Bruckmann, Caroline Hiefinger, Sílvia Osuna, Andrea Hupfeld

Abstract read
In one paragraph

Article in ACS catalysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mona WielandInstitute of Biophysics and Physical Biochemistry and Regensburg Center for Biochemistry, University of Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany.
Jonnely LuizagaInstitut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, c/Maria Aurèlia Capmany 69, 17003 Girona, Spain.
Cristina DuranInstitut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, c/Maria Aurèlia Capmany 69, 17003 Girona, Spain.
Barbara GermscheidInstitute of Biophysics and Physical Biochemistry and Regensburg Center for Biochemistry, University of Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany.
Johanna ReinInstitute of Biophysics and Physical Biochemistry and Regensburg Center for Biochemistry, University of Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany.
Astrid BruckmannInstitute of Biochemistry, Genetics and Microbiology, University of Regensburg, Universitatsstrasse 31, D-93053 Regensburg, Germany.
Caroline HiefingerInstitute of Biophysics and Physical Biochemistry and Regensburg Center for Biochemistry, University of Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany.
Sílvia OsunaInstitut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, c/Maria Aurèlia Capmany 69, 17003 Girona, Spain.ORCID https://orcid.org/0000-0003-3657-6469
Andrea HupfeldInstitute of Biophysics and Physical Biochemistry and Regensburg Center for Biochemistry, University of Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany.ORCID https://orcid.org/0000-0002-4341-1593

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photoswitchable unnatural amino acids are valuable engineering tools in biotechnology, particularly for the reversible control of enzymes with light. Here, we explore some basic principles of this protein engineering technique to simplify its approach and increase its success rate. To this end, we have selected

Identifiers

PMID40401100
PMCPMC12090219

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.