ArticleFrontiers in public health2025
U-shaped association between myeloperoxidase levels and anxiety risk: a cross-sectional study in a Chinese population.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Anxiety and peripheral artery disease.Clinical science (London, England : 1979) · 2026Review
- Association between hemoglobin-to-red cell distribution width ratio and depression in Chinese adults: a population-based cross-sectional study.Frontiers in public health · 2025Article
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Authors and funding
4 authors.
Funding
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Abstract
Objective: This study investigates the association between myeloperoxidase (MPO) levels and anxiety risk in Chinese adults and explores potential effect modifiers, with implications for neuroinflammatory biomarker-guided anxiety prevention strategies. Methods: Using cross-sectional data from 30,418 adults undergoing routine health examinations (July 2020-June 2021), anxiety severity was assessed via the Self-Rating Anxiety Scale (SAS; score ≥ 50 as clinically relevant). Plasma MPO was quantified by ELISA. Multivariate logistic regression, restricted cubic splines (RCS), threshold effect analysis, and subgroup interactions were conducted to evaluate nonlinear associations. Results: A U-shaped relationship between MPO and anxiety risk was identified. In fully adjusted models, participants in the lowest (Q1: ≤29.77 ng/mL, OR = 1.15, 95% CI: 1.03-1.28, Conclusion: Plasma MPO demonstrates a U-shaped association with anxiety risk independent of cardiometabolic confounders. Diabetic individuals exhibit heightened susceptibility to MPO-related anxiety, suggesting synergistic neuroinflammatory pathways. Monitoring MPO may aid in risk stratification and personalized interventions, particularly in populations with diabetes.
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