ArticleFrontiers in neurology2025
Elucidation of blink reflex characteristics in Parkinson's disease subtypes through prepulse inhibition.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The IC-SNc neural circuit mediates prepulse inhibition deficits in MPTP-induced Parkinson's disease male mice.NPJ Parkinson's disease · 2026Article
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9 authors.
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Abstract
This study investigated prepulse inhibition (PPI), a brainstem reflex, in Parkinson's disease (PD) patients. We compared PPI impairment between patients with postural instability and gait difficulty (PD-PIGD) and tremor-dominant (PD-TD) subtypes and explored potential lateralization effects. Fifty PD patients and 35 healthy controls underwent pre-pulse stimulation of the finger followed by stimulation of the supraorbital nerve. Compared to controls, PD patients exhibited impaired PPI across various stimulation intervals, with a more pronounced effect in the PD-PIGD subgroup. Interestingly, no significant differences in PPI were observed between the left and right sides, suggesting a bilateral effect. These findings suggest that abnormal brainstem circuits, potentially involving the pontine nucleus, contribute to PPI dysfunction in PD. Furthermore, the association between impaired PPI and the PD-PIGD subtype highlights a potential link with gait disturbances. Future research could explore the utility of PPI as a biomarker for gait dysfunction and treatment response in PD.
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