ArticleAmerican journal of clinical and experimental urology2025
Prognostic impact of extraprostatic extension on prostate cancer with seminal vesicle invasion.
Article in American journal of clinical and experimental urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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7 authors.
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Abstract
objectivesExtraprostatic extension (EPE) and seminal vesicle invasion (SVI) are unfavorable factors for biochemical recurrence (BCR) following radical prostatectomy; however, some patients with SVI survive for a long duration without experiencing BCR after prostatectomy in absence of adjuvant therapy. This study aimed to clarify the heterogeneity of locally advanced prostate cancers to better understand prognosis in patients with SVI.
methodsWe retrospectively reviewed the medical records of 120 patients with SVI who underwent radical prostatectomy at two institutions. Multivariate logistic regression was used to evaluate the preoperative clinical and postoperative pathological variables as predictors of BCR. We also used Kaplan-Meier and competing risk regression analysis to assess the cumulative incidence and risk of BCR. After excluding patients who received neoadjuvant or adjuvant therapy, 55 patients with SVI were enrolled in this study.
resultsBCR occurred in 31 of these patients (56.3%). We found that Grade group and positive EPE were predictors of BCR in patients with SVI (
conclusionsAmong the patients with SVI tumors, prognosis might be different depending on presence or absence of EPE.
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