ArticleJournal of thoracic disease2025
Tumor peripheral bronchial signature predicts spread through air spaces in resected invasive mucinous adenocarcinoma of the lung.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: While a higher incidence of spread through air spaces (STAS) has been reported in invasive mucinous adenocarcinoma (IMA) of lung, most studies have only focused on non-mucinous adenocarcinoma (ADC). In this study, tumor peripheral bronchial signature (TPBS) was defined as indicators to describe bronchial morphological changes and bronchial distribution characteristics around the tumor in the preoperative computed tomography (CT) images. The value of TPBS was examined in predicting STAS in patients with resected IMA. Methods: In the training cohort, the least absolute shrinkage and selection operator (LASSO) method was adopted to identify TPBS that was most strongly associated with STAS, and a formula of TPBS score was constructed. Subsequently, variations in clinical characteristics, radiological features, and TPBS scores were analyzed and compared using both univariate and multivariate statistical methods. Receiver operation characteristic (ROC) curve, decision curve, and calibration curve were employed to evaluate the model's efficacy. Results: The best predictors included clinical T classification, spiculated margin, combined pneumonia, consolidation-tumor ratio (CTR) and TPBS score. In addition, three different STAS prediction models were developed and the corresponding area under the curve (AUC) values were 0.904, 0.877 and 0.838, respectively. Calibration curve illustrated that the predicted probability value generated by the hybrid model aligned well with the actual STAS status. Moreover, decision curve analysis (DCA) suggested that the hybrid model provided superior clinical utility and application value compared to both the basic model and the TPBS model. Conclusions: TPBS score was identified as an independent predicting factor for STAS status. The nomogram, utilizing radiological features and TPBS score, demonstrated a high level of diagnostic accuracy and efficiency in predicting the status of STAS.
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