Evidence map›Paper›PMID 40400967›Full record

ArticleJournal of thoracic disease2025

Impact of biopsy number and radiologic pattern on diagnostic yield and complications of transbronchial lung cryobiopsy in interstitial lung diseases: a multi-center retrospective study.

Ranxun Chen, Lulu Chen, Hui Ge, Qingqing Xu, Qi Zhao, Yingwei Zhang, Fanqing Meng, Hourong Cai, Shuhong Guan, Chong Li and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Yield and safety of different biopsy types in interstitial lung disease: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026
    Pooled it
  2. Review
  3. Scoping out sarcoidosis: the evolving role of bronchoscopy.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ranxun Chen *Department of Pulmonary and Critical Care Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Lulu Chen *Department of Pulmonary and Critical Care Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Hui Ge *Department of Respiratory and Critical Care Medicine, Northern Jiangsu People's Hospital, Clinical Medical College, Yangzhou University, Yangzhou, China.
Qingqing XuDepartment of Pulmonary and Critical Care Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Qi ZhaoDepartment of Pulmonary and Critical Care Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Yingwei ZhangDepartment of Pulmonary and Critical Care Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Fanqing MengDepartment of Pathology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Hourong CaiDepartment of Pulmonary and Critical Care Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Shuhong GuanDepartment of Respiratory and Critical Care Medicine, Changzhou First People's Hospital, Changzhou, China.
Chong LiDepartment of Respiratory and Critical Care Medicine, Changzhou First People's Hospital, Changzhou, China.
Lingfeng MinDepartment of Respiratory and Critical Care Medicine, Northern Jiangsu People's Hospital, Clinical Medical College, Yangzhou University, Yangzhou, China.
Bi ChenDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Jinghong DaiDepartment of Pulmonary and Critical Care Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Given that transbronchial lung cryobiopsy (TBLC) is recommended as a surrogate for surgical lung biopsy (SLB) in the diagnosis of interstitial lung disease (ILD), few studies have evaluated the optimal number of biopsy sample or the impact of radiologic pattern on the diagnostic yield and postoperative complications. This study aimed to investigate how biopsy sample number and radiologic patterns affect diagnostic yield and complications. Methods: We conducted a multi-center retrospective study including 334 consecutive ILD patients who underwent TBLC. The impact of number of biopsy sample and radiologic pattern on diagnosis yields and postoperative complications was assessed. Logistic regression analyses were used to explore the risk factors for complications. Results: The histopathologic and multidisciplinary discussion (MDD) diagnostic yields were 70.06% (234/334) and 86.23% (288/334). Moderate-severe bleeding and pneumothorax occurred in 39 (11.68%) and 29 (8.68%) cases, respectively. The MDD diagnostic yield was higher in patients with non-fibrotic pattern on high-resolution computed tomography (HRCT) compared to those with a fibrotic pattern (88.11% Conclusions: This study showed that obtaining three biopsy samples is appropriate to achieve an adequate diagnostic yield, while procedure methods are associated with complications. Further well-designed studies are required to standardize TBLC procedures.

Indexed as

complicationsdiagnostic yieldinterstitial lung disease (ILD)Transbronchial lung cryobiopsy (TBLC)

Identifiers

PMID40400967
PMCPMC12090163

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.