Evidence map›Paper›PMID 40400963›Full record

ArticleJournal of thoracic disease2025

Preventive effect of Lianhua Qingwen capsule on close contacts of seasonal influenza in residential environments: protocol for a multicenter, randomized, double-blind, placebo-controlled study.

Yangqing Zhan, Zhonghao Fang, Yinhong Hu, Jincan Luo, Lili Hou, Yilin Li, Qiexinhao Li, Yuyue Liu, Chuoqi Yang, Shiwei Liang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Yangqing Zhan *National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhonghao Fang *National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yinhong Hu *National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Jincan Luo *National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Lili HouNational Key Laboratory for Innovation and Transformation of Luobing Theory, Shijiazhuang, China.
Yilin LiNational Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Qiexinhao LiNational Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yuyue LiuNational Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Chuoqi YangNational Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Shiwei LiangNational Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Kun ZhaoVanke School of Public Health, Tsinghua University, Beijing, China.
Nanshan ZhongNational Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zifeng YangNational Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Seasonal influenza poses a high risk of death worldwide. Lianhua Qingwen (LHQW) is effective in shortening the time to symptom alleviation in patients with influenza, but there is a lack of convincing clinical trials targeting influenza prevention. This study aims to evaluate both efficacy and safety of LHQW in the preventing spread of seasonal influenza among close contacts under a cluster setting. Methods: This study is a randomized, double-blind, multicenter clinical trial to evaluate the preventive efficacy and safety of LHQW in close contacts in a residential environments; 1,884 close contacts will be enrolled in this trial at 72 centers in China, with a five-day duration of LHQW or placebo. All participants were randomized into the LHQW and placebo groups in a 1:1 ratio via the interactive web response system (IWRS), balanced by the stochastic minimization method. Participants are required to undergo three visits (on days 3, 5, and 9 after initiation of medication). At each visit, a throat swab is collected from the participant, and RT-PCR is used to detect influenza virus nucleic acid. Symptom scoring will be performed nightly for the duration of the trial. The primary efficacy outcome was the secondary infection risk in close contacts on day 9 (±1) after medication. Safety outcomes are the incidence and severity of adverse events. This study used a randomized, double-blind, multicenter design method to evaluate the efficacy and safety of LHQW for close contacts in a congregate setting with risks of seasonal influenza transmission, to provide a valuable reference for clinical application. The treatment period of this study was five days and 1,884 close contacts were enrolled. All cases were randomized into experimental and placebo groups as index cases, and each subject returned three times during the treatment period on days 3, 5 and 9 after drug or placebo treatment, respectively, and the corresponding examinations were performed to evaluate the effect of the drug. Symptom scoring will be performed nightly for the duration of the trial. Discussion: This trial is the first seasonal influenza prevention study of traditional Chinese medicines concerning prophylactic effects globally. Positive findings could demonstrate the efficacy of LHQW against seasonal influenza, which provides a new therapeutic option for infection prevention, symptom alleviation, cost reduction, and renewal of treatment guideline. Trial Registration: The trial has been registered at Chinese Clinical Trial Registry (ChiCTR2300074385).

Indexed as

clinical trialinfluenzaLianhua Qingwen (LHQW)preventive effectresidential environment

Identifiers

PMID40400963
PMCPMC12090131

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.