ArticleJournal of thoracic disease2025
Three key factors predicting the severity of exacerbations of chronic obstructive pulmonary disease: T lymphocytes, lactate, and prealbumin.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Bioinformatics Screening and Preliminary Experimental Verification of Integrated Stress Response-Associated MYC and BAG3 in Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2026Article
- From metabolic alterations to chronic inflammation: mechanisms and immunoregulation of metabolic reprogramming in COPD.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a significant disease, and the main burden on global human health and economy. Currently, the pulmonary function test is the most common method for diagnosing AECOPD in clinical practice. The three levels (Grade I, II and III) of AECOPD exhibit different clinical characteristics and have a significant impact on the treatment and prognosis of patients. This study examined the correlation between serum lactic acid, pre-albumin, and lymphocyte levels, and the severity of AECOPD. Methods: A total of 261 patients with AECOPD were divided into the following three grades: Grade I: patients without respiratory failure. Grade II: patients with non-life-threatening respiratory failure; and Grade III: patients with life-threatening respiratory failure. The serum markers of the patients were analyzed. Flow cytometry was used to identify T, B, and natural killer (NK) lymphocyte subgroups, while immunoturbidimetry and an enzyme-linked immunosorbent assay (ELISA) were used to detect pre-albumin and lactic acid levels, respectively. Results: Cluster of differentiation (CD)3 Conclusions: Serum pre-albumin, lactate, and lymphocyte levels were found to be closely related to the severity of AECOPD, and could be potential biomarkers for clinical diagnosis.
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