ArticleJournal of thoracic disease2025
Photodynamic therapy as a promising treatment for long-segment and whole-circumferential early esophageal cancer.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Photodynamic therapy induces pyroptosis via GSDMD pathway in NCI-H226 human lung squamous carcinoma cells.Scientific reports · 2026Article
- Repeatable Photoactive Stent-Based Catheter to Enhance Therapeutic Efficacy for Esophageal Carcinoma.Biomaterials research · 2025Article
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Authors and funding
8 authors.
Funding
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Abstract
Background: Photodynamic therapy (PDT) is an effective endoscopic therapy indicated for early esophageal cancer, but there have been few reports of PDT for circumferential lesions so far. The objective of this study is to investigate the clinical outcome of PDT for patients with whole-circumferential early esophageal squamous cell carcinoma (ESCC), especially the subsequent process of esophageal stricture. Methods: Twelve patients with whole-circumferential early ESCC, who received PDT between January 2020 and July 2022 at the First Affiliated Hospital with Nanjing Medical University were retrospectively evaluated. An analysis for comparisons between the results of PDT and contemporaneous endoscopic submucosal dissection (ESD) for similar esophageal lesions was conducted. Results: The complete response (CR) rate was 83.33% after PDT treatment for a median tumor length of 9.5 cm. A longer tumor length (>10 cm) was the risk factor of PDT failure (P=0.045). Compared to the ESD group, the procedure was significantly shorter for PDT, and postoperative fever and bleeding seemed to occur less. Without prophylactic measures, the esophageal stricture rate was 80% after PDT, which was close to that in the ESD group with steroid administration (76.9%, P>0.99). The mean onset time of obvious dysphagia was 7.63±4.34 and 4.29±2.49 weeks respectively after PDT and ESD (P=0.02). The post-PDT esophageal strictures were easily resolved with a simpler dilation modality and the estimated dysphagia duration tended to be shorter than that after ESD (12.72±3.04 Conclusions: PDT can be expected to be an effective and safe endoscopic modality for long-segment and whole-circumferential early ESCC.
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