ArticleJournal of thoracic disease2025
Computed tomography characteristics of chronic bronchitis and its association with disease severity and clinical outcomes in viral pneumonia: a retrospective cohort study.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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7 authors.
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Abstract
Background: Chronic bronchitis (CB) patients' excessive mucus and airway changes may worsen viral pneumonia severity, but there is a lack of objective clinical/imaging assessment criteria. This study used quantitative computed tomography (CT) to link CB pathology with pneumonia severity/prognosis, guiding early interventions for high-risk groups. Methods: This retrospective cohort study included 42 patients with CB diagnosed with viral pneumonia and 208 non-CB viral pneumonia controls. Baseline demographic, clinical, and laboratory parameters were collected alongside thoracic CT-derived metrics, including mucus plugging score (a bronchopulmonary segment-based scoring system quantifying mucus obstruction severity), CT severity score (range, 0-25 per lobe), and emphysema quantification. Follow-up CT imaging was performed at 3 months post-diagnosis to assess pulmonary structural remodeling, with longitudinal documentation of CT severity scores. Participants were stratified into two cohorts by mucus plugging score: high mucus burden (≥4, group 1) and low mucus burden (<4, group 2). Intergroup comparisons utilized Fisher's exact test for categorical variables, with continuous variables analyzed via independent Results: This study enrolled 260 patients who were categorized into group 1 (n=42; CB prevalence: 35.70%) and group 2 (n=218; CB prevalence:19.70%). Comparative analysis demonstrated that CB patients in group 2 were significantly older [70, interquartile range (IQR) (62, 77) Conclusions: CB features-mucus hypersecretion, emphysema, and airway thickening-worsen viral pneumonia severity and prognosis. Key predictors include advanced age (OR =1.06), female sex (OR =3.39), and emphysema (OR =1.56). High-risk CB patients, especially with emphysema, need enhanced CT monitoring and therapies improving mucociliary clearance and airway repair.
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