ReviewCureus2025
Effects of Yoga on Gene Expression: A Systematic Review of Randomised Controlled Trials.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Effects of cyclic yoga on selected metabolic and hepatic parameters in diabetic women with fatty liver diseases: A clinical trial.Journal of clinical & translational endocrinology · 2026Article
- Management of type 2 diabetes mellitus using Yoga: Implications for immunological and autonomic dysfunction.Bioinformation · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Yoga, an integrative mind-body practice, is increasingly recognised for its ability to modulate gene expression, particularly that of genes associated with inflammation, stress, and aging. This systematic review, conducted per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, synthesises evidence from 11 randomised controlled trials (RCTs) from 2015 to 2024, involving over 700 adults. Studies were sourced from PubMed, Scopus, Web of Science, and the Cochrane Library to evaluate the molecular effects and clinical implications of yoga. Across these RCTs, yoga consistently downregulated pro-inflammatory genes - interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), and nuclear factor kappa B (NF-κB) - in five studies, and upregulated anti-inflammatory and immune-regulatory genes - transforming growth factor-beta (TGF-β), forkhead box P3 (FoxP3), soluble human leukocyte antigen G (sHLA-G), and IL-10 - in four studies. It also enhanced the expression of genes linked to deoxyribonucleic acid (DNA) repair (OGG1, or 8-oxoguanine DNA glycosylase), mitochondrial function (adenosine monophosphate-activated protein kinase (AMPK), and sirtuin 1 (SIRT-1)), and epigenetic regulation (e.g., reduced TNF methylation and increased microRNA-133B (miR-133B)). These molecular changes were associated with clinical benefits, including reduced disease activity in rheumatoid arthritis (RA), improved glycemic control in type 2 diabetes (T2D), and improved quality of life among breast cancer survivors. Despite these promising findings, the small sample sizes and short intervention durations limit statistical power and generalisability. Yoga shows potential as a complementary therapy for managing inflammation and age-related conditions, but larger, longer-term RCTs with standardised protocols are essential to substantiate its therapeutic value and elucidate its mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.