ArticleFrontiers in veterinary science2025
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- HDAC1 and SATB1 positively regulate immune responses in chicken macrophages.Poultry science · 2026Article
- Gut commensal Parabacteroides goldsteinii protects against Salmonella infection in mice by enhancing innate defense function.NPJ biofilms and microbiomes · 2026Article
- Multi-omics analysis reveals the potential for fermentedFrontiers in microbiology · 2026Article
- The gut microbiome in colorectal anastomotic leakage: from mechanisms to precision.Frontiers in medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The misuse of antibiotics threatens animal health and food safety and limits the development of livestock and poultry farming. In animal husbandry, probiotics can be used as an alternative to antibiotics because of their environmental protection and high efficiency. Methods: The results showed that cell viability with the PG supernatant was highest at a 20-fold dilution ratio. Exposure of IPEC-J2 cells to LPS (1 μg/mL) significantly increased IL-6 and IL-8 concentrations, which triggered an inflammatory response. PG attenuated the LPS-induced inflammatory response by inhibiting the release of pro-inflammatory cytokines (IL-6) and promoting the release of anti-inflammatory cytokines (IL-10). Transcriptome analysis showed that the average number of clean reads in the LPS and LPS-PG groups was 39,311,061 and 38,085,237, respectively. In total, 2,126 differentially expressed genes (DEGs) were identified between the LPS and LPS-PG groups, including 36 up-regulated and 2090 down-regulated genes. Some DEGs, such as IL-6R and NF-кB, are related to inflammation. GO analysis was used to annotate the functions of the DEGs, and the results showed that biological regulation, cellular anatomical entity, and binding were dominant. KEGG enrichment analysis showed that the DEGs were significantly enriched in the PI3K-AKT signaling pathway, protein export pathway, and antigen processing and presentation pathway. Discussion: These results indicate that
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.