ReviewFrontiers in medical technology2025
Molecular diagnostic methods for rapid diagnosis of central nervous system infections.
Review in Frontiers in medical technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Etiologic diagnosis of suspected tuberculous meningitis by multiplex PCR of cerebrospinal fluid.Journal of clinical microbiology · 2026Article
- Expanding Diagnostic Options for Pediatric Meningitis: BCID2 Testing Results on Cerebrospinal Fluid After a Negative Meningitis/Encephalitis Panel.Antibiotics (Basel, Switzerland) · 2026Article
- Implementation of the BIOFIRE Meningitis/Encephalitis Panel: A Mixed-Methods Implementation Study in a Nonmetropolitan Tertiary Hospital.Open forum infectious diseases · 2026Article
- Headache Attributed to Infection: A Clinical and Pathophysiological Overview.Current pain and headache reports · 2026Review
- Host-membrane lipid composition controlsFrontiers in immunology · 2025Article
- Clinical, Laboratory Characteristics, and Microorganism Infection Status in Neonates With Meningitis in Vietnam: A Cross-Sectional Descriptive Study.International journal of pediatrics · 2025Article
- Molecular mechanisms of streptococcal disruption of the blood-brain barrier and their pathogenic role in bacterial meningitis.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central nervous system infections (CNSI) are serious life-threatening conditions caused by bacteria, viruses, fungi, and parasites and lead to high morbidity and mortality worldwide. Therefore, rapid identification of causative organisms and appropriate treatment are important. The traditional identification methods are time-consuming and lack sensitivity and specificity. Although culture method is gold standard for CNSI, it is time-consuming and microbiology reporting requires several days. Multiplex PCR assays can detect multiple pathogens simultaneously in clinical samples and overcome the limitations of conventional identification techniques. Despite the availability of several commercial molecular-based platforms for the detection of pathogens causing CNSI, there are still limitations in terms of cost, false positive results, and false negative results, which are limited to targeted pathogens in the panel. Moreover, validation of many commercially available and in-house laboratory-developed molecular assays is still lacking. In addition, molecular diagnostic tests need to be used in correlation with the clinical context to ensure better diagnosis and management of infections.
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Registered trials
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