SynthesisFrontiers in medicine2025
Optimal exercise temporal parameters of Traditional Chinese Exercises for cognitive function of older adults with mild cognitive impairment: a systematic review and dose-response meta-analysis of randomized controlled trials.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.
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Who cites it
3 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of mindfulness-based exercise on Parkinson's disease and Alzheimer's disease: a systematic review and meta-analysis.Frontiers in neurology · 2026Pooled it
- Nonlinear dose-response of mind-body exercise in older adults with mild cognitive impairment: A systematic review and meta-analysis.PloS one · 2026Pooled it
- Crossing Pathological Boundaries: Multi-Target Restoration of the Neurovascular Unit in Alzheimer's and Vascular Dementia-From Modern Therapeutics to Traditional Chinese Medicine.Aging and disease · 2025Review
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Mild cognitive impairment (MCI) is characterized by a progressive decline in memory and other cognitive functions, falling between normal cognition and dementia. Traditional Chinese Exercises (TCEs) have been proven effective for managing MCI. A dose-response meta-analysis was conducted to evaluate the correlation between exercise temporal parameters and their effectiveness in older adults with MCI. Methods: Randomized controlled trials (RCTs) on TCEs for MCI were searched across eight databases from their inception to September 2024. Literature was screened based on inclusion and exclusion criteria. Data from the selected studies were extracted, and the risk of bias was assessed using the RoB2 tool. The quality of the included studies was evaluated using the PEDro scale. The visualizations were conducted using the "robvis" package in R 4.3.3 software, while Stata 15.0 software was used to analyze the dose-response relations. Result: Out of 2,216 records,17 RCTs were included in the meta-analysis. Although significant heterogeneity was present among the studies, sensitivity analysis demonstrated good robustness. The results revealed significant improvements in cognitive function among older adults with MCI in the TCEs group: Montreal Cognitive Assessment (MoCA) (SMD = 1.04, 95% CI: 0.71-1.38) and Mini-Mental State Examination (MMSE) (SMD = 0.82, 95% CI: 0.41-1.42). The relations between exercise cycle, frequency, and overall cognitive function (MoCA and MMSE) followed a " Conclusion: This study demonstrates a nonlinear dose-response relations between exercise temporal parameters and therapeutic effects on cognitive function in older adults with MCI. Regarding exercise cycle, MoCA and MMES yield the optimal outcomes at 12 and 13 weeks. For exercise frequency, MoCA and MMES optimize results at three times per week. Concerning exercise duration, MoCA achieves optimal results at 45 min; MMES shows gradual improvement after 30 min. Systematic review registration: The study protocol was registered with PROSPER on May 29, 2024, under the registration number CRD42024510378, https://www.crd.york.ac.uk/PROSPERO/view/CRD42024510378.
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