Evidence map›Paper›PMID 40400553›Full record

ArticleEnvironment & health (Washington, D.C.)2025

MPs Entering Human Circulation through Infusions: A Significant Pathway and Health Concern.

Tingting Huang, Yangyang Liu, Licheng Wang, Xuejun Ruan, Qiuyue Ge, Minglu Ma, Wei Wang, Wenbo You, Liwen Zhang, Ventsislav Kolev Valev and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment & health (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Dynamic Uptake and Elimination of Microplastics byEnvironment & health (Washington, D.C.) · 2026
    Article
  8. Effects of micro and nano plastics on renal health.World journal of nephrology · 2026
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tingting HuangShanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary, IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather, Department of Environmental Science & Engineering, Fudan University, Shanghai 200433, China.
Yangyang LiuShanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary, IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather, Department of Environmental Science & Engineering, Fudan University, Shanghai 200433, China.
Licheng WangShanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary, IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather, Department of Environmental Science & Engineering, Fudan University, Shanghai 200433, China.
Xuejun RuanShanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary, IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather, Department of Environmental Science & Engineering, Fudan University, Shanghai 200433, China.
Qiuyue GeShanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary, IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather, Department of Environmental Science & Engineering, Fudan University, Shanghai 200433, China.
Minglu MaShanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary, IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather, Department of Environmental Science & Engineering, Fudan University, Shanghai 200433, China.
Wei WangShanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary, IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather, Department of Environmental Science & Engineering, Fudan University, Shanghai 200433, China.
Wenbo YouShanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary, IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather, Department of Environmental Science & Engineering, Fudan University, Shanghai 200433, China.
Liwen ZhangIntensive Care Unit, Affiliated Hospital of Jining Medical University, Jining 272100, Shandong Province, China.
Ventsislav Kolev ValevCentre for Photonics and Photonic Materials and Centre for Nanoscience and Nanotechnology, Department of Physics, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.
Liwu ZhangShanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, National Observations and Research Station for Wetland Ecosystems of the Yangtze Estuary, IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather, Department of Environmental Science & Engineering, Fudan University, Shanghai 200433, China.ORCID https://orcid.org/0000-0002-0765-8660

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human uptake of microplastic particles (MPs) is causing increasing health concerns, and there is mounting pressure to evaluate the associated risks. While MPs can be ingested, breathed in, or drank in, a very direct entrance channel is available through ingress into the bloodstream. Intravenous infusion usually proceeds from plastic bottles. Many are made of polypropylene (PP), and filtering is applied to limit particle contamination. In this study, we examined the MPs' content of filtrates using a combination of surface-enhanced Raman spectroscopy and scanning electron microscopy. We find that the number of PP particles is significant (∼7500 particles/L). The MP sizes range from 1 to 62 μm, with a median of ∼8.5 μm. About 90% of particles ranged between 1 and 20 μm in size, with ∼60% in the range 1 to 10 μm. We then discuss the potential number of such particles injected and the consequences of their presence in the bloodstream. We highlight the organs for potential deposition, and we discuss possible clinical effects. Our quantitative data are important to help evaluate the toxicity risks associated with MPs and to accurately balance those risks versus the benefits of using intravenous injections.

Identifiers

PMID40400553
PMCPMC12090008

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.