Establishment and evaluation of an automatic multi?sequence MRI segmentation model of primary central nervous system lymphoma based on the nnU?Net deep learning network method.

Accurate quantitative assessment using gadolinium-contrast magnetic resonance imaging (MRI) is crucial in therapy planning, surveillance and prognostic assessment of primary central nervous system lymphoma (PCNSL). The present study aimed to develop a multimodal artificial intelligence deep learning segmentation model to address the challenges associated with traditional 2D measurements and manual volume assessments in MRI. Data from 49 pathologically-confirmed patients with PCNSL from six Chinese medical centers were analyzed, and regions of interest were manually segmented on contrast-enhanced T1-weighted and T2-weighted MRI scans for each patient, followed by fully automated voxel-wise segmentation of tumor components using a 3-dimenstional convolutional deep neural network. Furthermore, the efficiency of the model was evaluated using practical indicators and its consistency and accuracy was compared with traditional methods. The performance of the models were assessed using the Dice similarity coefficient (DSC). The Mann-Whitney U test was used to compare continuous clinical variables and the χ