ArticlePsychological medicine2025
Adverse childhood experiences and their differential relationships with transdiagnostic mental health outcomes in young adults.
Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Attachment insecurity, adverse childhood experiences (ACEs), and suicidality in French residential-care adolescents: a gender-differentiated study.Child and adolescent psychiatry and mental health · 2025Article
- Progression of Transdiagnostic Stages From Childhood to Young Adulthood.JAMA psychiatry · 2025Article
- Childhood adversities and their associations with mental disorders in the World Mental Health International College Student surveys initiative.Psychiatry research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Adverse childhood experiences (ACEs) are associated with poor mental health outcomes, which are increasingly conceptualized from a transdiagnostic perspective. We examined the impact of ACEs on transdiagnostic mental health outcomes in young adulthood and explored potential effect modification. We included participants from the Avon Longitudinal Study of Parents and Children with prospectively measured data on ACEs from infancy till age 16 as well as mental health outcomes at ages 18 and 24. Exposures included emotional neglect, bullying, and physical, sexual or emotional abuse. The outcome was a pooled transdiagnostic Stage of 1b (subthreshold but clinically significant symptoms) or greater level (Stage 1b+) of depression, anxiety, or psychosis - a clinical stage typically associated with first need for mental health care. We conducted multivariable logistic regressions, with multiple imputation for missing data. We explored effect modification by sex at birth, first-degree family history of mental disorder, childhood neurocognition, and adolescent personality traits. Stage 1b + outcome was associated with any ACE (OR = 2.66, 95% CI = 1.68-4.22), any abuse (OR = 2.08, 95% CI = 1.38-3.14), bullying (OR = 2.15, 95% CI = 1.43-3.24), and emotional neglect (OR = 1.68, 95% CI = 1.06-2.67). Emotional neglect had a weaker association with the outcome among females (OR = 1.14, 95% CI = 0.61-2.14) than males (OR = 3.49, 95% CI = 1.64-7.42) and among those with higher extraversion (OR = 0.91, 95% CI = 0.85-0.97), in unweighted (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.