Evidence map›Paper›PMID 40400436›Full record

ArticleEnvironmental analysis, health and toxicology2025

A critical review on the journey of benzoic acid in the pharmaceutical industry from manufacturing processes through various uses to disposal: An environmental perspective.

Hayder M Issa, Dania H Mohammed

Abstract read
In one paragraph

Article in Environmental analysis, health and toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. RSC advances · 2026
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hayder M IssaDepartment of Chemistry, College of Science, University of Garmian, Kalar, Sulaymaniyah, Iraq.
Dania H MohammedDepartment of Pharmacy, Al-Qalam University College, Kirkuk, Iraq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review provides a comprehensive evaluation of benzoic acid (BA) as a preservative and additive with a particular focus on its utilization in the pharmaceutical sector, its lifespan, and its environmental impact. The key aspects of this review offer significant additional perspectives on the relevant subject matter. The review suggests a thorough and organized analysis, likely incorporating multiple studies and sources, to provide a complete understanding of the subject. It suggests an in-depth study of BA's involvement and evolution in the pharmaceutical sector, spanning from the early stages of production to the final phases. It highlights the long-standing use of BA in pharmaceuticals, despite its associated toxicity issues. The review emphasizes its role as a versatile compound in the synthesis of more complex medicinal products, such as benzoyl peroxide. The review provides a lifecycle analysis through a comprehensive exploration of BA's lifecycle, from manufacturing processes to its various applications and eventual disposal. This involves evaluating its environmental consequences and emphasizing the significance of sustainability in its utilization. In terms of environmental considerations, the review offers a critical evaluation of how BA affects the environment; under certain conditions, it can form other compounds that become persistent organic pollutants. The review aims to provide insights and make a significant contribution to understanding the implications of BA in pharmaceuticals and its environmental footprint. Therefore, this study provides a comprehensive assessment that not only addresses the scientific and treatment aspects of BA but also evaluates the larger environmental consequences, making it relevant to ecology and environment experts.

Indexed as

benzoic acidenvironmental impactlifecyclepreservativessustainabilitytoxicity

Identifiers

PMID40400436
PMCPMC12187383

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.