Evidence map›Paper›PMID 40400235›Full record

ArticlePsychological medicine2025

Shared genetics and causal relationship between sociability and the brain's default mode network.

Giuseppe Fanelli, Jamie Robinson, Chiara Fabbri, Janita Bralten, Nina Roth Mota, Martina Arenella, Maroš Rovný, Emma Sprooten, Barbara Franke, Martien Kas and 2 more

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In one paragraph

Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Giuseppe FanelliDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.ORCID 0000-0001-7930-563X
Jamie RobinsonGlobal Computational Biology and Data Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany.
Chiara FabbriDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Janita BraltenDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Nina Roth MotaDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Martina ArenellaDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Maroš RovnýMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Emma SprootenDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Barbara FrankeDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Martien KasGroningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, The Netherlands.
Till F M AndlauerGlobal Computational Biology and Data Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany.
Alessandro SerrettiDepartment of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

Funding

2/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124851 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BOERGLUM, ANDERS, DAVIS, LEA K · 2021 to 2025
$5.4M
NIMH NIH HHS R01 MH124851
6 · The paper itself

Abstract

backgroundThe brain's default mode network (DMN) plays a role in social cognition, with altered DMN function being associated with social impairments across various neuropsychiatric disorders. However, the genetic basis linking sociability with DMN function remains underexplored. This study aimed to elucidate the shared genetics and causal relationship between sociability and DMN-related resting-state functional MRI (rs-fMRI) traits.

methodsWe conducted a comprehensive genomic analysis using large-scale genome-wide association study (GWAS) summary statistics for sociability and 31 activity and 64 connectivity DMN-related rs-fMRI traits (

resultsSignificant local genetic correlations were identified between sociability and two rs-fMRI traits, one representing spontaneous activity within the temporal cortex, the other representing connectivity between the cingulate and angular/temporal cortices. MR analyses suggested potential causal effects of sociability on 12 rs-fMRI traits. Seventeen genes were highly prioritized, with

conclusionsBy combining genomic and transcriptomic data, our gene prioritization strategy may serve as a blueprint for future studies. Our findings can guide further research into the biological mechanisms underlying sociability and its role in the development, prognosis, and treatment of neuropsychiatric disorders.

Indexed as

BrainDefault Mode NetworkSocial BehaviorAdultFemaleGenome-Wide Association StudyHumansMagnetic Resonance ImagingMaleMendelian Randomization Analysisbrain activitybrain connectivityexpression quantitative trait loci (eQTL)imaging geneticsneuroimagingresting-state functional magnetic resonance imaging (rs-fMRI)single-nucleus RNA sequencing (snRNA-seq)social withdrawal

Identifiers

PMID40400235
PMCPMC12115276

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.