Evidence map›Paper›PMID 40400173›Full record

ArticleAnnals of clinical and translational neurology2025

Serotonergic and Dopaminergic Function in Neuropsychiatrically Asymptomatic People With HIV on Antiretroviral Therapy.

Chuen-Yen Lau, Anna Lyndaker, Swati Shah, Paul Wakim, Amelia Mitchell, Cynthia Monroe, Alan Kim, Tracy L Cropper, Govind Nair, Joseph Snow and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chuen-Yen LauNational Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0002-4337-8885
Anna LyndakerCenter for Infectious Disease Imaging (CIDI), Radiology and Imaging Sciences, Clinical Center (CC), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Swati ShahCenter for Infectious Disease Imaging (CIDI), Radiology and Imaging Sciences, Clinical Center (CC), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Paul WakimBiostatistics and Clinical Epidemiology Service, Clinical Center, NIH, Bethesda, Maryland, USA.
Amelia MitchellCenter for Infectious Disease Imaging (CIDI), Radiology and Imaging Sciences, Clinical Center (CC), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Cynthia MonroeCenter for Infectious Disease Imaging (CIDI), Radiology and Imaging Sciences, Clinical Center (CC), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Alan KimCenter for Infectious Disease Imaging (CIDI), Radiology and Imaging Sciences, Clinical Center (CC), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Tracy L CropperRadiology and Imaging Sciences, Clinical Center (CC), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Govind NairTranslational Neuroradiology Section (D.S.R., G.N.), National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA.ORCID 0000-0003-3725-615X
Joseph SnowOffice of the Clinical Director, National Institute of Mental Health, NIH, Bethesda, Maryland, USA.
Bryan R SmithSection of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA.
Avindra NathSection of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA.ORCID 0000-0003-0927-5855
Dima A HammoudCenter for Infectious Disease Imaging (CIDI), Radiology and Imaging Sciences, Clinical Center (CC), National Institutes of Health (NIH), Bethesda, Maryland, USA.

Funding

CLC NIH HHS CL010357NCI NIH HHSNINDS NIH HHSOffice of AIDS Research
6 · The paper itself

Abstract

objectivePeople with HIV (PWH) on antiretroviral therapy (ART) still experience neurocognitive dysfunction and accelerated brain volume loss. To assess whether the serotonergic and dopaminergic systems are affected, we used [

methodsWe compared [

resultsBP INTERPRETATIONS: Presynaptic serotonin transporter density (measured by [

Indexed as

Anti-Retroviral AgentsBrainCognitive DysfunctionDopamineHIV InfectionsSerotoninAdultBenzylaminesFemaleHumansMaleMiddle AgedPositron-Emission TomographyAnti-Retroviral AgentsBenzylaminesDopamineN,N-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamineSerotonindopamineHIVPET imagingserotonin

Identifiers

PMID40400173
PMCPMC12257126

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.