ArticleContact dermatitis2025
The Italian Trend of Contact Allergy to 2-Hydroxyethyl Methacrylate: Is the Current European Legislation Working?
Article in Contact dermatitis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Reactions to Acrylates in Dentistry and Related Factors - The First Croatian Survey Study on Reactions to Acrylates in Dentistry.Acta stomatologica Croatica · 2026Article
- 2-Hydroxyethyl Methacrylate, Methyl Methacrylate and Ethyl Acrylate Sensitisation: A 7-Year Retrospective Study.Contact dermatitis · 2026Article
- The Italian Trend of Contact Allergy to 2-Hydroxyethyl Methacrylate: Is the Current European Legislation Working?Contact dermatitis · 2025Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background(Meth)acrylates are well-known causes of allergic contact dermatitis, and nail products are the major source of exposure, especially in a non-occupational setting. In 2020, the European legislation restricted 2-hydroxyethyl methacrylate (2-HEMA) only in nail cosmetics to professional use.
objectiveTo investigate the Italian prevalence trend of positive patch test reactions to 2-HEMA, the best marker for delayed hypersensitivity to (meth)acrylates.
methodsA retrospective descriptive study on consecutive patients patch tested with the Italian baseline series containing 2-HEMA was performed in 8 Italian Dermatology Clinics. Demographics, patch test results, exposure settings and sources were analysed.
resultsAmongst 7133 patch tested patients, 147 (2.1%) resulted positive to 2-HEMA with an increasing trend from 2019 (1.6%) to 2023 (2.7%). The median age of sensitised female patients with a relevant positive patch test reaction to 2-HEMA was significantly decreasing over time (p = 0.004). Non-occupational allergic contact dermatitis was documented in 68.7%; artificial nails were the leading source of exposure in both occupational (75.0%) and non-occupational (72.2%) settings.
conclusionThe prevalence of contact allergy to 2-HEMA in Italy shows a progressively increasing trend over time. Currently, the European legislation does not appear to be effective in preventing or reducing this phenomenon.
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