ArticleInternational journal of dermatology2025
Serum C-Reactive Protein as a Potential Indicator for Screening Fecal Calprotectin in Patients With Moderate-to-Severe Hidradenitis Suppurativa: A Cross-Sectional Cohort Study.
Article in International journal of dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHidradenitis suppurativa (HS) is a chronic inflammatory skin disorder frequently associated with immune-mediated comorbidities, including inflammatory bowel disease (IBD). Given the potential risk of IBD, particularly before initiating therapies such as interleukin (IL)-17 inhibitors, screening through a fecal calprotectin (FC) test may be warranted. While FC is a reliable, non-invasive biomarker for ruling out IBD, its cost and limited availability in dermatology settings present challenges. Therefore, this study aims to investigate the potential association between FC and serum C-reactive protein (CRP) levels in patients with moderate-to-severe HS, which may provide a more accessible screening approach.
methodThis cross-sectional cohort study was conducted at the Department of Dermatology and Venereology of Uşak University between April 2, 2024, and December 31, 2024, including 18-65-year-old patients with moderate-to-severe HS. Serum CRP and FC levels were analyzed using an enzyme-linked immunosorbent assay (ELISA).
resultsStool samples from 61 patients with moderate-to-severe HS were included. The median FC and serum CRP levels were 28.2 μg/g and 5.3 mg/L, respectively, with a significant correlation between them (rho = 0.289, p = 0.026). While FC levels did not significantly differ between moderate and severe HS, CRP levels were significantly higher in patients with severe disease (p = 0.009). Receiver operating characteristic (ROC) analysis identified a CRP cut-off of 5.35 mg/L for predicting FC ≥ 50 μg/g (AUC = 0.660, p = 0.045), with 70% sensitivity and 61.5% specificity.
conclusionPatients with moderate-to-severe HS and serum CRP levels above 5.35 mg/L may benefit from FC screening, and those with FC levels exceeding 50 μg/g may be considered for further endoscopic evaluation to assess IBD.
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