Evidence map›Paper›PMID 40400028›Full record

ArticleAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology2025

Association of myeloid cell reactivity patterns with safe food predictions in FPIES patients.

Georgiana M Sanders, Alexandra Hua, Elizabeth Hudson, Jonathan P Troost, Nobuhiko Kamada, John Y Kao, Charles F Schuler, Mohamad El-Zaatari

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04644783 (A Novel Blood Test to Predict Safe), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04644783 nacompletednot on this map

A Novel Blood Test to Predict Safe (Non-trigger) Foods for Infants and Toddlers With Food Protein-induced Enterocolitis Syndrome (FPIES)

TypeinterventionalSponsorUniversity of MichiganRan2019 to 2022Enrolled10ConditionsFood Protein-Induced Enterocolitis Syndrome, Allergies, Pediatric DisorderArmsBlood test assay
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Georgiana M SandersDivision of Allergy and Immunology, Department of Internal Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI, 48105, USA.
Alexandra HuaDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Elizabeth HudsonDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Jonathan P TroostMichigan Institute for Clinical and Health Research, University of Michigan, Ann Arbor, MI, USA.
Nobuhiko KamadaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, 6518 MSRB 1, 1150 W. Medical Center Drive, Ann Arbor, MI, 48109, USA.
John Y KaoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, 6518 MSRB 1, 1150 W. Medical Center Drive, Ann Arbor, MI, 48109, USA.
Charles F SchulerDivision of Allergy and Immunology, Department of Internal Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI, 48105, USA. schulerc@med.umich.edu.
Mohamad El-ZaatariDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, 6518 MSRB 1, 1150 W. Medical Center Drive, Ann Arbor, MI, 48109, USA. mohamade@med.umich.edu.

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Michigan Institute for Clinical and Health Research (MICHR)UM1TR004404 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Julie C Lumeng · 2023 to 2026
$39.8M
The role of epithelial barrier dysfunction in food anaphylaxisK23AI162661 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Charles F Schuler · 2022 to 2026
$972k
Bioinformatics Core of the University of Michigan Medical School's Biomedical Research Core Facilities RRID: SCR 019168Gerber Foundation 9026Michigan Institute for Clinical and Health Research UM1TR004404National Institute of Allergy and Infectious Diseases 1K23AI162661NCATS NIH HHS UL1TR002240NCATS NIH HHS UM1 TR004404NIAID NIH HHS K23 AI162661NIAID NIH HHS L30 AI171988
6 · The paper itself

Abstract

backgroundFood protein-induced enterocolitis syndrome (FPIES) is an understudied non-IgE-mediated food allergy, which is distinct from and lacks diagnostic testing akin to IgE testing. FPIES affects infants and toddlers but can persist into adulthood. As there are no extant methods to identify safe foods for FPIES patients, food ingestion trials are performed at home and often lead to reactions and development of food aversions, which may lead to failure-to-thrive and gastric feeding tube requirements. We hypothesized that foods that fail to elicit responses in immune cells of FPIES patients would be safe to ingest, which could support development of a diagnostic method to headstart safe food identification in patients.

methodsWe developed an ex vivo model of FPIES using food-stimulated white blood cells (WBCs) from pediatric FPIES patients and controls by defining a 9-gene panel representative of FPIES ex vivo responses and conducted a single-arm pilot clinical trial.

resultsMyeloid cells of FPIES patients displayed variable individual-specific myeloid cell reactivity patterns (iMCRPs) to different foods. Foods that failed to elicit repsonses in patients' immune cells were safe to ingest with a negative predictive value of 98.5%. This, when utilized in prospective predictions, reduced newly introduced food reaction rates from 19.5 to 0% while increasing food repertoire diversity.

conclusionsiMCRPs represent a novel and potentially useful tool that associates with safe food ingestion in FPIES patients for foods that fail to elicit immune cell reactions. Trial Registration The trial has been registered at registered at ClinicalTrials.gov # NCT04644783.

Indexed as

DiarrheaFood allergyFPIESGastrointestinal inflammationNon-IgE food allergyVomiting

Identifiers

PMID40400028
PMCPMC12093898

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.