ArticleParasites & vectors2025
Differences in human skin volatiles between populations with high and low attraction to mosquitoes.
Article in Parasites & vectors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Making scents of mosquito lures: semiochemical attractants for adult mosquitoes.Parasites & vectors · 2026Review
- Cyphers and cycles - A chemical basis of the differential attraction of mosquitoes to human odor.iScience · 2026Article
- Cymbopogon citratus and Lippia multiflora essential oils as alternative repellent to DEET against Anopheles gambiae s.l. in Bobo-Dioulasso, Burkina Faso.Scientific reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe attractiveness of mosquitoes to humans varies among individuals, with human volatile organic compounds (VOCs) playing a pivotal role in the mosquitoes' host-seeking behavior. Differences between human volatiles detected by GC-MS can effectively modulate mosquito host selection.
methodsParticipants were enrolled and then assessed for mosquito attraction via an olfactometer. Their skin volatiles were collected with a stir bar as the sorptive extraction and were analyzed with high-resolution gas chromatography-mass spectrometry (SBSE-HRGC-MS). These data were then integrated with principal component analysis (PCA), volcano plot analysis, and partial least squares discriminant analysis (PLS-DA) to identify differential compounds between high and low mosquito attraction groups. Odorants with repellent properties were screened and evaluated using behavioral bioassays to assess their impact on the attractiveness of Aedes aegypti.
resultsFrom the 30 volunteers, 24 participants (12/12 with high/low attractiveness to mosquitoes) were enrolled. In the group with high mosquito attraction, human skin compounds such as N,N-dibutyl formamide (10.8%), decanoic acid (9.2%), and decanal (5.9%) were detected with high components. Conversely, in the low mosquito attraction group, relatively high levels of indole (0.9%), fury hydroxymethyl ketone (2.2%), and 2-hydroxy-3-methyl-2-cyclopentenone (0.8%) were observed. The results of two pathway analyses indicated that most of these compounds are associated with fatty acid metabolism, respectively. Three compounds-2-hydroxy-3-methyl-2-cyclopentenone, furfuryl hydroxymethyl ketone, and 1,2-cyclopentanedione-were identified as prominent candidates, exhibiting significant repellent efficacy in behavioral bioassays.
conclusionsIn this study, the impact of differences among VOCs emitted by human skin on the host-seeking behavior of Ae. aegypti was investigated, providing insights for the development of novel mosquito baits and repellents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.