Evidence map›Paper›PMID 40399948›Full record

SynthesisRadiation oncology (London, England)2025

Stereotactic radiosurgery in pituitary metastases: a systematic review and meta-analysis.

Bardia Hajikarimloo, Salem M Tos, Mohammadamin Sabbagh Alvani, Alireza Kooshki, Ibrahim Mohammadzadeh, Dorsa Najari, Mohammad Amin Habibi

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Radiation oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bardia HajikarimlooDepartment of Neurosurgery, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. bardii47@yahoo.com.
Salem M TosDepartment of Neurological Surgery, University of Virginia, Charlottesville, VA, USA.
Mohammadamin Sabbagh AlvaniDepartment of Neurosurgery, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Alireza KooshkiStudent Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Ibrahim MohammadzadehSkull Base Research Center, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Dorsa NajariDepartment of Neurosurgery, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Amin HabibiDepartment of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe pituitary gland is an infrequent site for metastasis, encompassing approximately 0.4% of all intracranial metastatic lesions. The prognosis of pituitary metastasis (PM) remains dismal despite considerable advances in therapeutic interventions. Stereotactic radiosurgery (SRS) has been increasingly utilized as a minimally invasive therapeutic option for PMs. This study evaluated the efficacy and safety of SRS in patients with PMs.

methodsOn November 26, 2024, a systematic search was conducted through PubMed, Embase, Scopus, and Web of Science. Studies that have evaluated the role of SRS in PMs or PMs with cavernous sinus invasion were included. The meta-analysis, sensitivity analysis, publication bias evaluation, and meta-regression were conducted using the R program.

resultsSeven studies with 79 individuals with PMs were included. The results showed a pooled local control (LC) rate of 92% (95%CI:83-98%) following intervention. The analysis resulted in a pooled diabetes insipidus (DI) improvement rate of 42% (95%CI:0-100%) and cranial nerve (CN) dysfunction improvement rate of 77% (95%CI:49-98%). In contrast, none of the patients with anterior pituitary dysfunction experienced improvement. The meta-analysis revealed a pooled ARE rate of 2% (95%CI:0-7%) with low heterogeneity (I

conclusionSRS is correlated with promising improvement in LC, OS, and CN dysfunction in patients with PM. On the other hand, SRS is accompanied by limited effectiveness in DI and improvement in anterior pituitary dysfunction due to irreversible damage to the pituitary cells by metastatic lesions.

Indexed as

Pituitary NeoplasmsRadiosurgeryHumansCavernous sinusGamma knifePituitary metastasisStereotactic radiosurgery

Identifiers

PMID40399948
PMCPMC12096573

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.