Evidence map›Paper›PMID 40399920›Full record

Trial reportBMC musculoskeletal disorders2025

Contextual and placebo effects of suboccipital myofascial release: evaluating its influence on pain threshold, cervical range of motion, and proprioception.

Ertuğrul Safran, Yaren Kaya

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06761391 (Immediate Effects of Suboccipital Myofascial Release on Pain Pressure Threshold, Range of Motion, Balance, and Proprioception), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06761391 nacompletednot on this map

Immediate Effects of Suboccipital Myofascial Release on Pain Pressure Threshold, Range of Motion, Balance, and Proprioception

TypeinterventionalSponsorBezmialem Vakif UniversityRan2024 to 2024Enrolled30ConditionsSuboccipital MusclesArmsPain Pressure Threshold, Cervical Range of Motion, Balance Error Scoring, Cervical Joint Position Sense, Suboccipital manual therapy
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ertuğrul SafranFaculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Bezmialem Vakıf University, Silahtarağa Street No: 189, Alibeyköy Eyüp İstanbul, 34050, Turkey. esafran@bezmialem.edu.tr.ORCID http://orcid.org/0000-0002-6835-5428
Yaren KayaInstitute of Health Sciences, Department of Physiotherapy and Rehabilitation, Bezmialem Vakıf University, Silahtarağa Street No: 189, Alibeyköy Eyüp İstanbul, 34050, Turkey.ORCID http://orcid.org/0009-0007-4551-3722

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSuboccipital myofascial release (MR) is widely used in manual therapy for addressing cervical dysfunction. However, its specific therapeutic effects remain unclear, especially when compared to sham interventions, raising questions about the roles of contextual and placebo influences.

objectiveThis study aimed to evaluate the immediate effects of suboccipital MR on pain pressure threshold(PPT), cervical range of motion (ROM), and proprioception, while considering the influence of non-specific effects such as placebo and contextual factors.

methodsA single-blind, sham-controlled randomized study was conducted with 30 asymptomatic participants (15 per group). The MR group received five minutes of suboccipital myofascial release, while the sham group received light touch without therapeutic pressure.Outcomes included PPT, cervical ROM (flexion, extension, and rotation), and proprioception, measured before and immediately after the intervention. A 2 × 2 mixed ANOVA was used to analyze group × time interaction and main effects. Paired t-tests were used as supportive within-group analyses.

resultsThe MR group showed within-group improvements in PPT (e.g., left-side PPT increased from 7.31 ± 2.58 to 8.67 ± 1.98 kg/cm², p = 0.028), cervical ROM (e.g., flexion improved from 57.00 ± 9.05° to 64.00 ± 9.60°, p = 0.0004), and proprioception (e.g., flexion reposition error decreased from 5.77 ± 2.24° to 3.70 ± 2.40°, p = 0.006). However, no significant group × time interactions were observed for any outcome, suggesting similar changes in both MR and sham groups.

conclusionsSuboccipital MR produced significant within-group improvements in PPT, cervical ROM, and proprioception. However, the absence of significant differences between the MR and sham interventions suggests that non-specific or contextual factors may account for the observed effects. Further studies are needed in symptomatic populations with longer follow-up and objective outcome measures to determine the specific efficacy of MR.

trial registrationThis study was retrospectively registered with ClinicalTrials.gov under the identifier NCT06761391 on January 5, 2025.

Indexed as

Cervical VertebraeNeck PainPain ThresholdProprioceptionRange of Motion, ArticularAdultFemaleHumansMalePlacebo EffectSingle-Blind MethodTreatment OutcomeYoung AdultMyofascial releasePainProprioceptionRange of motionSham treatmentSuboccipital muscles

Identifiers

PMID40399920
PMCPMC12093650

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.