SynthesisBMC oral health2025
Exploring the link between periodontal disease and sperm quality: a comprehensive systematic review study.
Synthesis in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Chromosomal Instability and Periodontal Disease in Idiopathic Infertility: Evidence of a Possible Association.Biology · 2025Article
- Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriodontal diseases are among the most prevalent oral health conditions globally, with evidence suggesting their systemic effects, including potential impacts on male reproductive health. Inflammation associated with periodontitis might interfere with spermatogenesis and alter sperm parameters such as count, motility, morphology, and DNA integrity. This systematic review aims to critically assess existing studies on the relationship between periodontal disease and sperm quality to delineate its clinical implications for male infertility.
methodsThe research was registered in the International Prospective Register of Systematic Reviews (PROSPERO) at the National Institute for Health Research (PROSPERO code: CRD420251005800). A comprehensive literature search was conducted across multiple databases, including PubMed, EMBASE, ProQuest, Scopus, Web of Science (WOS), and Google Scholar, up to September 2024. Inclusion criteria targeted human studies reporting associations between periodontal health and sperm quality parameters. To assess the quality of the included studies, the Newcastle-Ottawa Scale (NOS) was used. Data were synthesized qualitatively and analyzed for trends.
resultsNine studies encompassing 1,386 participants were included. Evidence suggests a significant association between periodontitis and decreased sperm motility, abnormal morphology, and increased DNA fragmentation. However, findings on sperm count and concentration were inconsistent. Mechanistic pathways suggest that inflammatory cytokines and oxidative stress contribute to these disruptions.
conclusionThis review highlights the systemic implications of periodontal disease on male reproductive health. Given the global decline in male fertility, maintaining oral health may serve as an adjunct strategy in managing infertility. Future research should prioritize large-scale, longitudinal studies to establish causality and explore preventive interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.