Evidence map›Paper›PMID 40399869›Full record

ArticleBMC psychiatry2025

Evaluation of a school-based depression prevention approach among adolescents with elevated depressive symptoms attending special education: study protocol of a cluster randomized controlled trial.

Wendy C H Rongen, Daan H M Creemers, Jan Spijker, Ad A Vermulst, Sanne P A Rasing

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06203899 (Strong Teens and Resilient Minds), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06203899 narecruitingnot on this map

Strong Teens and Resilient Minds: School-based Depression and Suicide Prevention in Adolescents Attending Special Schools

TypeinterventionalSponsorGgz Oost BrabantRan2023 to 2027Enrolled236ConditionsDepressive SymptomsArmsOp Volle Kracht, Gatekeeperstraining
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wendy C H RongenBehavioural Science Institute, Radboud University, Nijmegen, The Netherlands. wendy.rongen@ru.nl.
Daan H M CreemersBehavioural Science Institute, Radboud University, Nijmegen, The Netherlands.
Jan SpijkerBehavioural Science Institute, Radboud University, Nijmegen, The Netherlands.
Ad A VermulstCentre of Excellence for Youth Depression (CEYD) at GGZ Oost Brabant, Mental Health Care Institution, Oss, The Netherlands.
Sanne P A RasingBehavioural Science Institute, Radboud University, Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdolescents are at risk of developing depressive symptoms and suicidality. Those attending special education, because of cognitive, physical, behavioral, emotional or learning disabilities, form a particularly vulnerable subgroup concerning the development of depressive disorders. Despite the fact that school-based prevention programs effectively reduce the risk of developing a depressive disorder in adolescents, approximately 7% of Dutch adolescents attend special education and remain unreached. There is also a lack of knowledge about effectiveness of depression and suicide prevention in this group. This study aims to evaluate the effectiveness of the adapted indicated prevention program 'At Full Force - Special Needs Education' for adolescents attending special education presenting elevated depressive symptoms.

methodsWe will perform a cluster randomized controlled trial (RCT) to test the effectiveness of an indicated prevention program 'At Full Force - Special Needs Education'. Participating schools will randomly be assigned to the intervention or control condition. A safety net consisting of gatekeepers will be realized at every school. Adolescents will be screened for depressive symptoms. Those with heightened levels of depressive symptoms can participate in the RCT. Participants in the intervention condition will receive a CBT-based prevention group training during school hours, comprising eight meetings of 45 min each. The training is a modified version of a previously studied training in general education called At Full Force (in Dutch: Op Volle Kracht). The control condition consists of care as usual. All participants and their parents will complete assessments at baseline, post-intervention and 6- and 12 months follow-up. At all times, adolescents will be guided to mental health care if necessary. The primary outcome will be depressive symptoms. Secondary outcomes will be suicidality, anxiety and somatic symptoms. Additional exploratory analyzes will be conducted. DISCUSSION: Adolescents in special education usually encounter numerous challenges. Adolescents participating in the preventive training are expected to show lower levels of depressive symptoms at follow-up compared to the control condition. Depression prevention can favorably impact pre-existing psychopathology trajectories and can avert additional life challenges associated with depression.

trial registrationClinicaltrials.gov NCT06203899 on January 2nd 2024. PROTOCOL VERSION: May 6th 2025 (v2.1).

Indexed as

Cognitive Behavioral TherapyDepressionDepressive DisorderEducation, SpecialSchool Mental Health ServicesAdolescentFemaleHumansMaleNetherlandsRandomized Controlled Trials as TopicSuicide PreventionAdolescentsDepressionPreventionSchool-basedSpecial Needs Education

Identifiers

PMID40399869
PMCPMC12096628

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.