ArticleBMC psychiatry2025
Differential relationships among homocysteine levels, cognitive deficits, and low-frequency fluctuation in brain activity in bipolar disorder with suicidal ideation.
Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- The Brain-Gut Health Initiative (BIGHI): A Prospective Cohort on Psychiatric Disorders in China.Research (Washington, D.C.) · 2026Review
- Clozapine Drug-Drug Interactions and Individualized Dosing in Bipolar Disorder: A Model-Informed Precision Dosing Approach.Drug design, development and therapy · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundSuicidal ideation (SI) is a common symptom of bipolar disorder (BD). Patients with BD and suicidal ideation (BDSI) have been shown to exhibit abnormal spontaneous brain activity and homocysteine (Hcy) levels. Additionally, cognitive deficits are also considered to be a critical symptom in BD. However, the relationship among spontaneous brain activity, Hcy levels, and cognitive deficits in patients with BDSI remains unclear.
methodsA total of 74 participants were enrolled, comprising individuals with BDSI (n = 20), BD patients without suicidal ideation (BDNSI) (n = 24), and age-/sex-matched healthy controls (HC) (n = 30). Each participant underwent cognitive performance assessments, and blood samples were collected to measure Hcy levels. We then calculated the amplitude of low-frequency fluctuation (ALFF) from resting-state functional magnetic resonance imaging data. Mediated-effects analysis was conducted to explore the association among these three variables.
resultsHcy levels were significantly higher in the BDNSI group than in the BDSI group (t = 2.33, P = 0.024). Specifically, a significant positive correlation was observed between Hcy levels and the fractional amplitude of low-frequency fluctuation (fALFF) signals in the left posterior cingulate gyrus in the BDSI group (r = 0.644, P = 0.005). Mediation analyses revealed that the left posterior cingulate gyrus significantly mediated the negative relationship between Hcy levels and both visual learning /verbal learning performance (95% confidence intervals for the indirect effects ranging from [Formula: see text]0.592 to [Formula: see text]0.069 and [Formula: see text]0.465 to [Formula: see text]0.042, respectively) in the BDSI group.
conclusionsOur data suggest that patients with BDSI and BDNSI may exhibit distinct Hcy-neurocognitive-brain function profiles, which could be further verified by investigating the underlying pathophysiological mechanism of BDSI.
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