Evidence map›Paper›PMID 40399826›Full record

ArticleBMC medical imaging2025

Assessment of muscle fiber types transformation in rats with discogenic low back pain using diffusion tensor image of paraspinal muscles.

Ying Wu, Jiyao Ma, Yilong Huang, Zhenguang Zhang, Jiangyuan Pi, Chao Gao, Wenyang Leng, Bo He

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Article in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Ying WuDepartment of Radiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Jiyao MaDepartment of Radiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Yilong HuangDepartment of Radiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Zhenguang ZhangDepartment of Radiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Jiangyuan PiKunming Medical University, Kunming, Yunnan, China.
Chao GaoDepartment of Radiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Wenyang LengDepartment of Radiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Bo HeDepartment of Radiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. kmmu_hb@163.com.

Funding

National Natural Science Foundation of China 82260338
6 · The paper itself

Abstract

backgroundThe onset of discogenic lower back pain (DLBP) was strongly associated with fiber-type transformation in the paraspinal muscles. Management of DLBP would be greatly benefited from an objective, noninvasive biomarker for assessing fiber composition. Our study aimed to explore the value of diffusion tensor imaging (DTI) in evaluating fiber-type transformation, which contributed to improve diagnosis and intervention strategies on DLBP.

methodsAccording to time since model establishment, ninety healthy female Sprague Dawley rats were randomly divided into the 1st month group,3rd month group, and 6th month group, then each group was subdivided into the DLBP group, sham-operated group, and control group. The L4/5 and L5/6 intervertebral discs of rats underwent posterior-entry puncture disruption and sham-operation to establish DLBP and sham-operation groups. DTI MRI and immunofluorescence (IF) were performed to assess fiber type transformation.

resultsThe DLBP rats exhibited a gradual decrease in Fractional Anisotropy (FA) values. At the 3rd month and 6th month after modeling, there was a significant decrease in the percentage of type I fiber, while an increase in the percentage of type II fiber. Notably, the percentage of type I fiber demonstrated a moderate positive correlation with FA values.

conclusionDTI may serve as a potential tool to investigate the fiber type transformation in DLBP rats. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Diffusion Tensor ImagingIntervertebral Disc DegenerationLow Back PainMuscle Fibers, SkeletalParaspinal MusclesAnimalsAnisotropyDisease Models, AnimalFemaleRatsRats, Sprague-DawleyDiffusion tensor imageDiscogenic low back painMuscle fiber type transformationRats

Identifiers

PMID40399826
PMCPMC12096766

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.