ArticleBMC pregnancy and childbirth2025
Placental histological differences between COVID19 infected and non-infected mothers during third trimester of pregnancy: a retrospective cohort study.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCovid-19 infection was revealed to be associated with higher risk of maternal and fetal morbidity and mortality. Knowing that Covid-19 virus can infect the placenta, the aim of this study is to investigate placental histological differences between Covid-19 uncomplicated pregnancies and Covid-19 infected mothers in the 3rd trimester or intrapartum.
methodsThis was a retrospective cohort study conducted between the 28th of January 2021 and the 31st of June of the same year at Saint George University Medical Hospital, Beirut-Lebanon. All pregnant women, whether symptomatic or not, were tested for Covid-19 infection via PCR upon presentation for delivery. We randomly collected placentas from Covid-19 uncomplicated gestations and 3rd trimester or intrapartum Covid-19 infected mothers after obtaining an informed consent. Our control population included all previously healthy mothers, singleton, term, and uncomplicated pregnancies regardless of the mode of delivery during the same period of the study. The Covid- 19 infected group had similar medical and obstetrical background only for coronavirus infection during the 3rd trimester or upon admission. Placentas of the two groups were grossly and histologically examined by a single pathologist who was blinded to the placentas of each group. Examination was based on the Amsterdam Consensus Statement guidelines.
resultsA total of 22 Covid-19 positive cases and 21 Covid-19 negative cases were included. The results showed no statistical significance for any of the placental pathologies including maternal vascular malperfusion, amniotic fluid infection including maternal response and fetal response, villitis of unknown etiology, intervillositis and chorangiosis and fetal vascular malperfusion, except for the vascular ectasia, were 5 cases were identified in the Covid-19 positive group (p < 0.05).
conclusionCovid-19 infection during the 3rd trimester of pregnancy is not a risk factor for the development of placental histopathologies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.