Trial reportBMC anesthesiology2025
Development and validation of a nomogram to pediatric postoperative pulmonary complications following thoracic surgery.
Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Risk factors, pathogenesis, and botanical drugs interventions for postoperative pulmonary complications after cardiothoracic surgery: a narrative review.Journal of thoracic disease · 2026Review
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Authors and funding
6 authors.
Funding
Abstract
backgroundSince the respiratory anatomy and physiology of children differ from those of adults, they are more susceptible to postoperative pulmonary complications after thoracic surgery that requires one-lung ventilation. Hypothesizing that the incidence of postoperative pulmonary complications could be predicted using easily accessible perioperative variables, we aimed to develop a nomogram specifically for children receiving thoracic surgery with one-lung ventilation.
methodsA total of 361 children undergoing thoracic surgery with one-lung ventilation were randomly assigned to two groups: a training cohort (80%) and a validation cohort (20%). The training cohort was utilized to develop a nomogram, whereas the validation cohort was used to assess its performance. The outcome of this study was the incidence of postoperative pulmonary complications. Univariate analysis and the least absolute shrinkage and selection operator regression model were applied to select the most relevant prognostic predictors. Multivariable logistic regression was used to develop a nomogram based on the selected prediction factors. Internal validation was conducted to evaluate its performance. The C-index and calibration plots were used to assess its discriminative ability and calibration.
resultsAmong the included patients, 109 (30.2%) presented postoperative pulmonary complications. Four predictive factors were ultimately selected to develop the nomogram. They were preoperative neutrophil-to-lymphocyte ratio, intraoperative ventilation mode, maximum peak airway pressure and minimum oxygenation index during one-lung ventilation. By incorporating these factors, the nomogram demonstrated strong C-indices of 0.909 (95% confidence interval (CI) [0.809-0.82]) and 0.871 (95% CI [0.795-0.945]) in the training and validation cohorts, respectively, along with well-matched calibration curves.
conclusionThe nomogram, based on four objective and easily assessed factors, demonstrates excellent predictive performance for pediatric postoperative pulmonary complications after one-lung ventilation, enabling early risk assessment and targeted interventions to improve patient outcomes.
trial registrationThis study is registered at the Chinese Clinical Trial Registry (Registration number: ChiCTR2300072042, Date of Registration: 1/6/2023).
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