ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Physical and biopsychosocial frailty, cognitive phenotypes, and plasma biomarkers for Alzheimer's disease in Chinese older adults: A population-based study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Global Prevalence of Cognitive Frailty in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists · 2026Pooled it
- From Cerebrospinal Fluid to Blood Draw: Plasma p-Tau217 as a Non-Invasive Biomarker for Alzheimer's Disease: A Fagan Nomogram-Based Meta-Analytic Study.Molecular neurobiology · 2026Pooled it
- Interpretable multimodal MRI fusion in Alzheimer's disease classification using extended parallel multilink joint ICA and 3D ResNet.iScience · 2026Article
- Integrating frailty into decision-making for disease-modifying therapies in Alzheimer's disease: a proposed expert-opinion based approach.The journal of prevention of Alzheimer's disease · 2026Review
- Accumulation of Biopsychosocial Risk Factors and Cognitive Impairment: The Impact of Slower Gait, Depression, and Low Education in Community-Dwelling Older Adults.Annals of geriatric medicine and research · 2026Article
- Interpreting p-tau217 on the ward: frailty and plasma biomarkers in acutely admitted older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Joint trajectories of sleep deviation risk and frailty and their associations with cognitive decline in middle-aged and older adults: a population-based cohort study.BMC public health · 2026Article
- The application value of frailty assessment tools in the perioperative period: A narrative review.Journal of anesthesia and translational medicine · 2026Review
- Association between physical exercise and cognitive frailty among community-dwelling older adults: the mediating role of self-efficacy.Frontiers in public health · 2026Article
- Physical and biopsychosocial frailty, cognitive phenotypes, and plasma biomarkers for Alzheimer's disease in Chinese older adults: A population-based study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Alisol A ameliorates vascular cognitive impairment via AMPK/NAMPT/SIRT1-mediated regulation of cholesterol and autophagy.Theranostics · 2025Article
- Deep medullary vein abnormalities associated with cognitive function and Alzheimer's disease plasma biomarkers in dementia-free older adults: A population-based study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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16 authors.
Funding
Abstract
introductionWe sought to examine the associations of physical frailty (PF) and biopsychological frailty (BF) with dementia and mild cognitive impairment (MCI) among Chinese older adults and further to explore neuropathological mechanisms underlying the associations.
methodsThis population-based cross-sectional study included 5149 participants in the MIND-China baseline examination (2018); of these, we measured plasma amyloid-β (Aβ), neurofilament light chain (NfL), and total tau in 1371 persons and phosphorylated tau 217 (p-tau217) and glial fibrillary acidic protein (GFAP) in 3387 persons.
resultsPF and BF were significantly associated with increased likelihoods of dementia, Alzheimer's disease (AD), vascular dementia (VaD), and MCI. PF was significantly correlated with increased plasma p-tau217, GFAP, and NfL, and reduced Aβ42/Aβ40 ratio; BF was related to higher plasma total tau and NfL and lower Aβ42/Aβ40 ratio. PF in combination with demographics performed excellent in differentiating dementia from non-dementia (area under the curve [AUC] = 0.83). DISCUSSION: PF and BF are potential clinical biomarkers for dementia and MCI in older adults. Alzheimer's pathology, neuroinflammation, and neurodegeneration may underlie their associations. HIGHLIGHTS: Physical (PF) and biopsychosocial frailty (BF) were strongly associated with dementia and mild cognitive impairment (MCI) in rural Chinese older adults. Frailty, especially PF, was associated with increased plasma phosphorylated tau 217 (p-tau217), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) and a reduced plasma amyloid-β (Aβ)42/Aβ40 ratio. Alzheimer's pathology, neuroinflammation, and neurodegeneration may underlie the associations of frailty with dementia. PF, in combination with demographic factors, performed excellent (area under the curve [AUC] = 0.83) in differentiating dementia from non-dementia in rural older adults.
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