ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Slow wave synchrony during NREM sleep tracks cognitive impairment in prodromal Alzheimer's disease.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- One night of closed-loop auditory stimulation during sleep enhances memory consolidation in patients with Alzheimer's Disease.medRxiv : the preprint server for health sciences · 2026Article
- Are infraslow oscillations the missing link between sleep and Alzheimer's?Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Cyclic alternating pattern in sleep electroencephalography as a novel predictor of dementia: A prospective study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Implication of the thalamus in sleep alterations observed in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Circadian syndrome (CircS) and cognitive trajectory deterioration in middle-aged and older adults: A national cohort study with causal forest analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- A machine learning-enabled blood transcriptomic signature for digital diagnosis and subtyping of Alzheimer's disease.NPJ digital medicine · 2026Article
- Resting-State EEG Characteristics of Tardive Dyskinesia: Spectral and Network Connectivity Insights.Neuropsychiatric disease and treatment · 2026Article
- Noradrenergic Slow Vasomotion: The Hidden Fluid Pump Linking Sleep, Brain Clearance, and Dementia Pathogenesis.International journal of molecular sciences · 2025Review
- Dementia Risk and Machine Learning-Derived Brain Age Index from Sleep Electroencephalography: A Pooled Cohort Analysis of Over 7,000 Individuals Across Five Community Cohorts.medRxiv : the preprint server for health sciences · 2025Article
- Slow wave synchrony during NREM sleep tracks cognitive impairment in prodromal Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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10 authors.
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Abstract
introductionAlzheimer's disease (AD) disrupts human sleep architecture more severely than normal aging. However, it remains unclear how AD changes oscillatory neural activity during sleep, and whether such changes foreshadow cognitive decline in AD.
methodsWe used high-density electroencephalography sleep recordings in 55 participants: (1) 21 healthy older adults, (2) 28 patients with amnestic mild cognitive impairment (aMCI)-a prodromal AD stage, and (3) 6 AD patients.
resultsCognitive performance robustly decreases with the slow wave (SW) trough amplitude and its synchronization across broad frontocentral cortical areas. Thus, across the AD spectrum, slow wave synchrony declines with cognition, as in normal aging, but at an accelerated pace. Moreover, delayed rapid eye movement (REM) sleep onset in aMCI and AD patients was associated with deficient SW activity, suggesting insufficiently restorative non-REM sleep. DISCUSSION: These findings suggest that impaired slow waves are closely linked to cognitive impairment and mark disrupted neural activity in AD progression. HIGHLIGHTS: Detailed analysis of high-density sleep electroencephalography was performed in amnestic mild cognitive impairment and Alzheimer's disease (AD) patients. Cognitive status robustly correlates with slow wave trough and its cortical spread. Delayed rapid eye movement sleep onset associated with AD correlates with diminished slow wave troughs. Impaired slow waves mark progressively disrupted neural activity in prodromal AD.
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