Evidence map›Paper›PMID 40399731›Full record

ReviewAesthetic plastic surgery2025

Stem-Cell-Assisted Lipotransfer and Platelet-Rich Plasma in Breast Reconstruction: A Literature Review.

Aikaterini-Gavriela Giannakaki, Aikaterini Stylianaki, Maria-Nektaria Giannakaki, Sophia Koura, Eutychia Papachatzopoulou, Ioannis Papapanagiotou, Dimitris Baroutis, Dionysia Rompoti, Spyros Marinopoulos, Eleni-Sivylla Bikouvaraki and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Aesthetic plastic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Aikaterini-Gavriela GiannakakiFirst Department of Obstetrics and Gynecology, Alexandra University Hospital, National and Kapodistrian University of Athens, 11528, Athens, Greece. giannakaki.katerina@gmail.com.
Aikaterini StylianakiFirst Department of Obstetrics and Gynecology, Alexandra University Hospital, National and Kapodistrian University of Athens, 11528, Athens, Greece.
Maria-Nektaria GiannakakiMedical School, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
Sophia KouraFirst Department of Obstetrics and Gynecology, Alexandra University Hospital, National and Kapodistrian University of Athens, 11528, Athens, Greece.
Eutychia PapachatzopoulouFirst Department of Obstetrics and Gynecology, Alexandra University Hospital, National and Kapodistrian University of Athens, 11528, Athens, Greece.
Ioannis PapapanagiotouFirst Department of Obstetrics and Gynecology, Alexandra University Hospital, National and Kapodistrian University of Athens, 11528, Athens, Greece.
Dimitris BaroutisFirst Department of Obstetrics and Gynecology, Alexandra University Hospital, National and Kapodistrian University of Athens, 11528, Athens, Greece.
Dionysia RompotiFirst Department of Obstetrics and Gynecology, Alexandra University Hospital, National and Kapodistrian University of Athens, 11528, Athens, Greece.
Spyros MarinopoulosFirst Department of Obstetrics and Gynecology, Alexandra University Hospital, National and Kapodistrian University of Athens, 11528, Athens, Greece.
Eleni-Sivylla BikouvarakiLaboratory of Cell and Gene Therapy, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Dimitriοs KarathanasisAllegene PHARMALABS GmbH, 1020, Vienna, Austria.
Dimitriοs PappasAllegene PHARMALABS GmbH, 1020, Vienna, Austria.
Kalliopi PappaFirst Department of Obstetrics and Gynecology, Alexandra University Hospital, National and Kapodistrian University of Athens, 11528, Athens, Greece.
Georgios DaskalakisFirst Department of Obstetrics and Gynecology, Alexandra University Hospital, National and Kapodistrian University of Athens, 11528, Athens, Greece.
Constantine DimitrakakisFirst Department of Obstetrics and Gynecology, Alexandra University Hospital, National and Kapodistrian University of Athens, 11528, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAutologous fat transplantation to the breast, a minimal invasive technique, has significantly expanded in aesthetic and reconstructive surgery over the past two decades. Initially used for lumpectomy defects or correcting contour deformities post-breast reconstruction, it is now also performed as a stand-alone technique for primary breast augmentation or as a complementary method to implant-based augmentation. However, this surgical technique is associated with a high absorption rate. The use of fat grafts for breast augmentation remains controversial due to concerns about its safety, efficacy, and impact on breast cancer.

methodsThis review examines the literature on cell-assisted lipotransfer (CAL) and PRP-assisted lipotransfer, comparing fat graft survival, complication rates, and oncological safety with conventional autologous lipotransfer.

resultsCAL and PRP-assisted lipotransfer techniques demonstrate improved fat graft retention and reduced complications compared to conventional methods. Several studies report a potential reduction in the absorption rate of fat grafts with improvements in aesthetic outcomes.

conclusionsWhile CAL and PRP-assisted lipotransfer have shown promising results in enhancing fat graft survival and reducing complications, there are still concerns about their oncological safety. NO LEVEL ASSIGNED: This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Indexed as

Adipose TissueMammaplastyPlatelet-Rich PlasmaStem Cell TransplantationEstheticsFemaleGraft SurvivalHumansRisk AssessmentTransplantation, AutologousTreatment OutcomeAdipose tissue-derived stem cellsAutologous fat graftBreastCell-assisted lipotransferPlatelet-rich plasma

Identifiers

PMID40399731
PMCPMC12618409

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.