ArticleMarine biotechnology (New York, N.Y.)2025
Differential Methylation Analysis of Hypermelanosis in Chinese Tongue Sole (Cynoglossus semilaevis).
Article in Marine biotechnology (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Hypermelanosis on the blind side is a major concern in tongue sole (Cynoglossus semilaevis) aquaculture in China and causes great economic loss for farmers. To investigate the relationship between DNA methylation and hypermelanosis, different skin tissues on both the ocular and blind sides of both normal and hypermelanotic fish were used in this study, and set analysis was utilized to narrow and filter the possible, potential, and direct differentially methylated regions (DMRs). A total of 2278, 1015, and 6740 DMRs were discovered, which belonged to 1786, 908, and 4210 genes, for possible, potential, and direct methylation types, respectively. Enrichment analysis revealed that the genes harboring DMRs associated with hypermelanosis were involved in the development of the skeletal system and embryonic organs during morphogenesis. Tens of key genes were mutually found by comparing methylation results with reported transcriptomic, ncRNA, and genetic studies. These results implied that hypermelanosis on the blind side in tongue sole is a complex trait that is affected by both genetic factors and environmental conditions and is regulated by a complicated gene network.
Indexed as
Identifiers
40399721What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.