SynthesisJournal of assisted reproduction and genetics2025
Sequential embryo transfer efficacy in enhancing pregnancy outcomes: a systematic review and meta-analysis.
Synthesis in Journal of assisted reproduction and genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Impact of Cleavage and Blastocyst Stage Sequential Transfer on Clinical Pregnancy Outcomes of Frozen Embryo Transfer in Patients with Multiple Transplant Failures: A Retrospective Cohort Study.International journal of women's health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSequential embryo transfer (SEQET) can increase the availability of embryos at various stages within the implantation window, thus improving the outcomes of assisted conception. This research seeks to analyze and synthesize clinical information on the influence of SEQET on in vitro fertilization (IVF) embryo transfer outcomes.
methodsThe literature search was done through four databases, which are Pubmed, Web of Science, Scopus, and Cochrane. The inclusion criteria are clinical trials or observational studies comparing sequential embryo transfer (cleavage and blastocyst) to single-day embryo transfer (cleavage or blastocyst) in women undergoing IVF. Data was collected from the included studies and analyzed by RevMan software.
resultsTwenty-three studies fulfilled the criteria for inclusion in this study. We found that SEQET showed significant improvement in clinical and chemical pregnancy rates (P < 0.00001) in comparison to the cleavage embryo transfer (CET) group. Moreover, implantation rates (P = 0.002) and live births (P = 0.006) were significantly greater. In comparing SEQET to blastocyst transfer, SEQET was associated with a significant increase in the clinical pregnancy rate (P = 0.003).
conclusionThis research discovered that sequential embryo transfer significantly enhanced live birth, clinical pregnancy, chemical pregnancy, and implantation rates compared to cleavage transfer. SEQET also improved clinical pregnancy rates compared to blastocyst transfer. However, there was no significant difference between the two groups in terms of live birth, implantation rates, or miscarriages.
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