Evidence map›Paper›PMID 40399701›Full record

ReviewCardiovascular and interventional radiology2025

Key Osteoarthritis Biomarkers: What Interventional Radiologists Performing Genicular Artery Embolization Need to Know.

David-Dimitris Chlorogiannis, Bedros Taslakian, Osman Ahmed, Attur Mukundan, Ali Guermazi, Anish Ghodadra, Venkatesh P Krishnasamy, Wali Badar, Yan Epelboym

Abstract readReview
PubMed Publisher
In one paragraph

Review in Cardiovascular and interventional radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. We Saved the Best for Last….Cardiovascular and interventional radiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David-Dimitris ChlorogiannisDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 St Francis Str, Boston, MA, 02215, USA. dchlorogiannis@bwh.harvard.edu.ORCID http://orcid.org/0000-0003-1596-9466
Bedros TaslakianDepartment of Radiology, Division of Vascular and Interventional Radiology, NYU Langone Health, New York, NY, 10016, USA.
Osman AhmedDepartment of Radiology, University of Chicago Medical Center, University of Chicago, Chicago, IL, 60637, USA.
Attur MukundanDivision of Rheumatology, Department of Medicine, NYU Langone Health, New York, NY, 10016, USA.
Ali GuermaziDepartment of Radiology, VA Boston Healthcare System, Chobanian & Avedisian Boston University School of Medicine, Boston, MA, 02215, USA.
Anish GhodadraDepartment of Radiology, University of Pittsburgh Medical Center, 200 Lothrop Street, Suite E204, Pittsburgh, PA, 15213, USA.
Venkatesh P KrishnasamyDivision of Interventional Radiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Wali BadarDepartment of Radiology, University of Chicago Medical Center, University of Chicago, Chicago, IL, 60637, USA.
Yan EpelboymDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 St Francis Str, Boston, MA, 02215, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Knee osteoarthritis (OA) is a major cause of pain and disability. Genicular artery embolization (GAE) is a promising alternative for patients unresponsive to conservative treatment or unsuitable for total knee replacement. GAE may alleviate knee pain by reducing synovitis and by causing ischemia to pathologic knee nerves. However, outcomes vary based on baseline MRI and radiographic findings, making patient selection challenging. Recently, reduction in synovitis on contrast-enhanced MRI has been associated with pain relief post-GAE. Novel OA phenotypes (inflammatory, cartilage, bone, and atrophic) can aid in patient selection by using imaging and molecular biomarkers. Moreover, imaging features such as cartilage defects, bone marrow lesions, and synovitis may predict symptomatic outcomes. This review explores OA pathophysiology, focusing on radiographic, biochemical, and imaging biomarkers in evaluating GAE for knee OA treatment.

Indexed as

Embolization, TherapeuticOsteoarthritis, KneeRadiography, InterventionalRadiology, InterventionalBiomarkersHumansMagnetic Resonance ImagingBiomarkersEmbolizationGenicular artery embolizationKneeOsteoarthritisPain

Identifiers

PMID40399701

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.