Evidence map›Paper›PMID 40399682›Full record

ArticleNature2025

Multigenerational cell tracking of DNA replication and heritable DNA damage.

Andreas Panagopoulos, Merula Stout, Sinan Kilic, Peter Leary, Julia Vornberger, Virginia Pasti, Antonio Galarreta, Aleksandra Lezaja, Kyra Kirschenbühler, Ralph Imhof and 3 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Cancer: From a Genetic Disorder to a Systemic Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  6. International journal of molecular sciences · 2025
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Andreas Panagopoulos *Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-7787-6938
Merula Stout *Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-6643-7860
Sinan KilicDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-5009-8884
Peter LearyFunctional Genomics Center Zurich, ETH Zurich and University of Zurich, Zurich, Switzerland.
Julia VornbergerDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-3139-8168
Virginia PastiDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.ORCID 0009-0005-0002-1893
Antonio GalarretaDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-2358-7927
Aleksandra LezajaDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.
Kyra KirschenbühlerDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.ORCID 0009-0003-2515-0224
Ralph ImhofDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.
Hubert RehrauerFunctional Genomics Center Zurich, ETH Zurich and University of Zurich, Zurich, Switzerland.ORCID 0000-0001-7612-9394
Urs ZieglerCenter for Microscopy and Image Analysis, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-7860-1867
Matthias AltmeyerDepartment of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland. matthias.altmeyer@uzh.ch.ORCID 0000-0003-3780-1170

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell heterogeneity is a universal feature of life. Although biological processes affected by cell-to-cell variation are manifold, from developmental plasticity to tumour heterogeneity and differential drug responses, the sources of cell heterogeneity remain largely unclear

Indexed as

Cell LineageCell TrackingDNA DamageDNA ReplicationSingle-Cell AnalysisCell CycleCRISPR-Cas SystemsDNA RepairEpigenesis, GeneticGene EditingHumansPolyploidy

Identifiers

PMID40399682
PMCPMC12176655

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.