ArticleNature2025
Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Configurational diversity of metabotropic glutamate receptor complexes with beta-arrestins.Nature communications · 2026Article
- Atypical signaling, ligand recognition and selective agonist discovery of complement receptor C5aR2.Cell research · 2026Article
- Arrestins as programmable integrators of GPCR signaling: structural microstates, spatiotemporal logic, and therapeutic control.Cell discovery · 2026Review
- UsingbioRxiv : the preprint server for biology · 2026Article
- Structural dynamics of kappa opioid receptor interactions with β-arrestin 1.Nature communications · 2026Article
- Elevated conformational dynamics makes ACKR3 activation-prone and G protein-incompetent.bioRxiv : the preprint server for biology · 2026Article
- GPCR kinases shape ACKR4 functions via differential C-terminal phosphorylation.Nature communications · 2026Article
- Subtype-dependent arrestin engagement of the metabotropic glutamate receptors.Nature communications · 2026Article
- Core conformation of arrestin coupling to parathyroid hormone type 1 receptor.Nature communications · 2026Article
- Cooperative Control of Arrestin Activation By Membrane Lipids And Phosphorylation Barcodes.bioRxiv : the preprint server for biology · 2026Article
- Phosphorylation site topology governs the functional dynamics of arrestin recruitment to GPCRs.Research square · 2026Article
- Deceptive beauty of non-natural structures.Protein science : a publication of the Protein Society · 2026Review
- Distinct membrane binding properties of the two non-visual arrestins.Communications biology · 2026Article
- The Functional Role of Gate Loop Residues in Arrestin Binding to GPCRs.International journal of molecular sciences · 2025Article
- Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies.Nature communications · 2025Article
- Novel atypical G protein-coupled receptor (GPCR)-arrestin complexes: a structural snapshot of the barcode hypothesis.Signal transduction and targeted therapy · 2025Article
- G protein-coupled receptor kinase 3 couples atypical chemokine receptor 4 independent of G proteins.Molecular pharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Qiuyan ChenDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA. qch2@iu.edu.ORCID 0000-0002-6263-6843
Christopher T SchaferSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-9907-295X
Somnath MukherjeeDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-5447-4496
Kai WangSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-8983-8077
Martin GustavssonSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-3015-2043
James R FullerHelix Biostructures, LLC, Indianapolis, IN, USA.ORCID 0000-0002-9029-0923
Katelyn TepperDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Thomas D LammeDepartment of Medicinal Chemistry, Amsterdam Institute for Molecular and Life Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0009-0005-2168-9809
Yasmin AydinDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Parth AgrawalDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Genki TerashiDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.ORCID 0000-0002-5339-909X
Xin-Qiu YaoDepartment of Chemistry, University of Nebraska Omaha, Omaha, NE, USA.
Daisuke KiharaDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA.ORCID 0000-0003-4091-6614
Anthony A KossiakoffDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.ORCID 0000-0003-3174-9359
Tracy M HandelSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA. thandel@ucsd.edu.ORCID 0000-0002-2558-6138
John J G TesmerDepartment of Biological Sciences, Purdue University, West Lafayette, IN, USA. jtesmer@purdue.edu.ORCID 0000-0003-1125-3727
Funding
Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI ANDREW D MESECAR · 1985 to 2026
$43.4MStructure, function, and inhibition of G protein-coupled receptor kinasesR01HL071818 · NHLBI · UNIVERSITY OF TEXAS AUSTIN · PI TESMER, JOHN · 2004 to 2023
$7.1MChaperone-Assisted Structure Determination of Membrane ProteinsR01GM117372 · NIGMS · UNIVERSITY OF CHICAGO · PI ANTHONY A KOSSIAKOFF · 2016 to 2026
$4.0MIt's a tug of war: structure, consequences, and inhibition of CXCR4 and ACKR3 responses to lymphocyte chemoattractant CXCL12R01AI161880 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HANDEL, TRACY M, KUFAREVA, IRINA · 2021 to 2025
$3.4MRegulation of the metastasis promoting chemokine receptor ACKR3 by GPCR kinases, Gβγ and arrestinsR01CA254402 · NCI · PURDUE UNIVERSITY · PI HANDEL, TRACY M, TESMER, JOHN · 2020 to 2024
$3.2MGPCR - Linked RhoGEFs in Tumor Growth and MetastasisR01CA221289 · NCI · PURDUE UNIVERSITY · PI TESMER, JOHN · 2018 to 2022
$1.9MBuilding protein structure models for intermediate resolution cryo-electron microscopy mapsR01GM133840 · NIGMS · PURDUE UNIVERSITY · PI KIHARA, DAISUKE · 2020 to 2023
$1.6MStructural Basis and Molecular Mechanism of GPCR-Arrestin InteractionsR35GM151033 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI Qiuyan Chen · 2023 to 2026
$1.6MBiased agonsim of CXCL12 stimulation of the atypical and classical receptors, ACKR3 and CXCR4F32GM137505 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHAFER, CHRISTOPHER T · 2020 to 2022
$163kNCI NIH HHS P30 CA023168NCI NIH HHS R01 CA221289NCI NIH HHS R01 CA254402NHLBI NIH HHS R01 HL071818NIAID NIH HHS R01 AI161880NIGMS NIH HHS F32 GM137505NIGMS NIH HHS R01 GM117372NIGMS NIH HHS R01 GM133840NIGMS NIH HHS R35 GM151033
Abstract
Unique phosphorylation 'barcodes' installed in different regions of an active seven-transmembrane receptor by different G-protein-coupled receptor (GPCR) kinases (GRKs) have been proposed to promote distinct cellular outcomes
Indexed as
ArrestinsReceptors, CXCRbeta-Arrestin 1beta-Arrestin 2G-Protein-Coupled Receptor Kinase 2G-Protein-Coupled Receptor Kinase 5HumansImmunoglobulin Fab FragmentsModels, MolecularPhosphorylationProtein BindingACKR3 protein, humanarrestin3Arrestinsbeta-Arrestin 1beta-Arrestin 2G-Protein-Coupled Receptor Kinase 2G-Protein-Coupled Receptor Kinase 5GRK2 protein, humanGRK5 protein, humanImmunoglobulin Fab FragmentsReceptors, CXCR
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.